UNC13D

Gene Symbol UNC13D
Entrez Gene 201294
Alt Symbol FHL3, HLH3, HPLH3, Munc13-4
Species Human
Gene Type protein-coding
Description unc-13 homolog D (C. elegans)
Other Description protein unc-13 homolog D
Swissprots B4DWG9 Q9H7K5 Q70J99
Accessions EAW89322 EAW89323 EAW89324 Q70J99 AJ578444 CAE17516 AK024474 BAB15764 AK300316 BAG62068 AK301529 BAG63031 AW451853 BC024740 BC067084 AAH67084 EU831417 ACE87104 EU831510 ACE86429 XM_011524504 XP_011522806 XM_011524505 XP_011522807 XM_011524506 XP_011522808 XM_011524507 XP_011522809 XM_011524508 XP_011522810 NM_199242 NP_954712
Function Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. {ECO:0000269|PubMed:15548590, ECO:0000269|PubMed:17237785}.
Subcellular Location Cytoplasm. Membrane; Peripheral membrane protein. Late endosome. Recycling endosome. Lysosome. Note=Colocalizes with cytotoxic granules at the plasma membrane. Localizes to endosomal exocytic vesicles.
Tissue Specificity Expressed at high levels in spleen, thymus and leukocytes. Also expressed in lung and placenta, and at very low levels in brain, heart, skeletal muscle and kidney. Expressed in cytotoxic T-lymphocytes (CTL) and mast cells. {ECO:0000269|PubMed:14622600, ECO:0000269|PubMed:15548590}.

Munc13-4 (C-12) - sc-271301 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Munc13-4 (C-12): sc-271301. Western blot analysis of Munc13-4 expression in non-transfected: sc-117752 (A) and human Munc13-4 transfected: sc-177578 (B) 293T whole cell lysates.

Munc13-4 (C-2) - sc-271300 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Munc13-4 (C-2): sc-271300. Western blot analysis of Munc13-4 expression in HeLa whole cell lysate.

Munc13-4 (G-16) - sc-54632 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Munc13-4 (H-150) - sc-50465 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Munc13-4 (H-150): sc-50465. Western blot analysis of Munc13-4 expression in 293T (A) and HeLa (B) whole cell lysates.

Munc13-4 (P-16) - sc-54633 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Munc 13-4 antibody - ab77057 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
ab77057, at 2.5µg/ml, staining Munc 13-4 in paraffin-embedded Human Thymus. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Anti-Munc 13-4 antibody - ab169245 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-Munc 13-4 antibody (ab169245) at 1 µg/mlLane 1 : Munc 13-4 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

Anti-Munc 13-4 antibody - ab96671 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-Munc 13-4 antibody (ab96671) at 1/500 dilution + Molt-4 whole cell lysate at 30 µg

Anti-Munc 13-4 antibody - ab15723 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-Munc 13-4 antibody (ab15723) at 2 µg/ml + Cell lysates prepared from human T lymphocytes at 35 µgdeveloped using the ECL technique

Anti-Munc 13-4 antibody [EPR4914] - ab109113 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4914
All lanes : Anti-Munc 13-4 antibody [EPR4914] (ab109113) at 1/1000 dilutionLane 1 : A673 cell lysateLane 2 : K562 cell lysateLane 3 : HepG2 cell lysateLane 4 : Molt-4 cell lysateLane 5 : RAW264.7 cell lysateLysates/proteins at 10 µg per lane.

Anti-Munc 13-4 antibody [EPR4915] - ab109297 from Abcam

Host Rabbit
Clonality Monoclonal
Clone EPR4915
All lanes : Anti-Munc 13-4 antibody [EPR4915] (ab109297) at 1/1000 dilutionLane 1 : Jurkat cell lysateLane 2 : HuT-78 cell lysateLane 3 : JAR cell lysateLane 4 : Human placenta tissue lysateLane 5 : Human tonsil tissue lysateLysates/proteins at 10 µg per lane.

Anti-Munc 13-4 antibody - N-terminal - ab152158 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Munc 13-4 antibody - N-terminal (ab152158) at 1/1000 dilution + A431 whole cell lysate at 30 µg

Anti-UNC13D Antibody (clone 1F4) - LS-C338450 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1F4
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY UNC13D (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-UNC13D.

Anti-UNC13D Antibody (C-Terminus) - LS-C187314 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human Fetal Lung . UNC13D antibody dilution 1.0 ug/ml.

Anti-UNC13D Antibody (C-Terminus, clone EPR4915) - LS-C138214 from LifeSpan Bioscience

Prices $450.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4915
IHC of paraffin-embedded human tonsil tissue using anti-Munc 13-4 antibody.

Anti-UNC13D Antibody (clone 2C7) - LS-C139185 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2C7
UNC13D monoclonal antibody (M05), clone 2C7. Western blot of UNC13D expression in NIH/3T3.

Anti-UNC13D Antibody (aa1079-1090) IHC-plus™ - LS-B1748 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-UNC13D / Munc13-4 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1748 concentration 5 ug/ml.

Anti-UNC13D Antibody (Internal, clone EPR4914) IHC-plus™ - LS-B7386 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4914
Anti-UNC13D / Munc13-4 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7386 dilution 1:50.

Anti-UNC13D Antibody (aa967-980) IHC-plus™ - LS-B1749 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-UNC13D / Munc13-4 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1749 concentration 5 ug/ml.

Anti-UNC13D Antibody (aa1029-1090) - LS-C185948 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded Stomach using UNC13D antibody at 1:100 dilution.

UNC13D/Munc 13-4 Antibody - NBP1-31072 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

UNC13D/Munc 13-4 Antibody - NB100-41385 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Western Blot: UNC13D/Munc 13-4 Antibody [NB100-41385] - 2ug/ml) staining of Human T-lymphocyte lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

UNC13D/Munc 13-4 Antibody (EPR4914) - NBP1-95723 from Novus Biologicals

Prices $349.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4914
Western Blot: Munc 13-4 Antibody (EPR4914) [NBP1-95723] (A) A673, (B) K562, © HepG2, (D) Molt-4, and (E) RAW264.7 cell lysates.

UNC13D/Munc 13-4 Antibody - NBP2-19442 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Munc 13-4 Antibody [NBP2-19442] - Sample (50 ug of whole cell lysate) A: Mouse Lung, 5% SDS PAGE gel, diluted at 1:500.

UNC13D/Munc 13-4 Antibody (2C7) - H00201294-M05 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2C7
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