UNC13D

Gene Symbol UNC13D
Entrez Gene 201294
Alt Symbol FHL3, HLH3, HPLH3, Munc13-4
Species Human
Gene Type protein-coding
Description unc-13 homolog D (C. elegans)
Other Description protein unc-13 homolog D
Swissprots B4DWG9 Q9H7K5 Q70J99
Accessions EAW89322 EAW89323 EAW89324 Q70J99 AJ578444 CAE17516 AK024474 BAB15764 AK300316 BAG62068 AK301529 BAG63031 AW451853 BC024740 BC067084 AAH67084 EU831417 ACE87104 EU831510 ACE86429 XM_011524504 XP_011522806 XM_011524505 XP_011522807 XM_011524506 XP_011522808 XM_011524507 XP_011522809 XM_011524508 XP_011522810 NM_199242 NP_954712
Function Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. {ECO:0000269|PubMed:15548590, ECO:0000269|PubMed:17237785}.
Subcellular Location Cytoplasm. Membrane; Peripheral membrane protein. Late endosome. Recycling endosome. Lysosome. Note=Colocalizes with cytotoxic granules at the plasma membrane. Localizes to endosomal exocytic vesicles.
Tissue Specificity Expressed at high levels in spleen, thymus and leukocytes. Also expressed in lung and placenta, and at very low levels in brain, heart, skeletal muscle and kidney. Expressed in cytotoxic T-lymphocytes (CTL) and mast cells. {ECO:0000269|PubMed:14622600, ECO:0000269|PubMed:15548590}.

Munc13-4 CRISPR/Cas9 KO Plasmid (h) - sc-404319 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Munc13-4 HDR Plasmid (h) - sc-404319-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Munc13-4 Double Nickase Plasmid (h) - sc-404319-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Munc13-4 Double Nickase Plasmid (h2) - sc-404319-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Munc13-4 CRISPR Activation Plasmid (h) - sc-404319-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Munc13-4 CRISPR Activation Plasmid (h2) - sc-404319-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Munc13-4 Lentiviral Activation Particles (h) - sc-404319-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Munc13-4 Lentiviral Activation Particles (h2) - sc-404319-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Munc13-4 siRNA (h) - sc-62651 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Munc13-4 shRNA Plasmid (h) - sc-62651-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Munc13-4 shRNA (h) Lentiviral Particles - sc-62651-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

UNC13D/Munc 13-4 RNAi - H00201294-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU153741 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22496 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22496 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR06642 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr06642

UNC13D siRNA (Human) - CRJ6289 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

UNC13D - MBS8215867 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human UNC13D (NM_199242.2) - SHH440512 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human UNC13D(NM_199242.2) - SHH223980 from Creative biogene

Category siRNA
Species Reactivities Human

Human UNC13D siRNA - orb276790 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

UNC13D shRNA Plasmid (Human) - CHJ6289 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

UNC13D miRNA 3'UTR clone - MiUTR1H-11011 from Creative biogene

Species Reactivities Human
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