UNC13D

Gene Symbol	UNC13D
Entrez Gene	201294
Alt Symbol	FHL3, HLH3, HPLH3, Munc13-4
Species	Human
Gene Type	protein-coding
Description	unc-13 homolog D (C. elegans)
Other Description	protein unc-13 homolog D
Swissprots	B4DWG9 Q9H7K5 Q70J99
Accessions	EAW89322 EAW89323 EAW89324 Q70J99 AJ578444 CAE17516 AK024474 BAB15764 AK300316 BAG62068 AK301529 BAG63031 AW451853 BC024740 BC067084 AAH67084 EU831417 ACE87104 EU831510 ACE86429 XM_011524504 XP_011522806 XM_011524505 XP_011522807 XM_011524506 XP_011522808 XM_011524507 XP_011522809 XM_011524508 XP_011522810 NM_199242 NP_954712
Function	Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. {ECO:0000269|PubMed:15548590, ECO:0000269|PubMed:17237785}.
Subcellular Location	Cytoplasm. Membrane; Peripheral membrane protein. Late endosome. Recycling endosome. Lysosome. Note=Colocalizes with cytotoxic granules at the plasma membrane. Localizes to endosomal exocytic vesicles.
Tissue Specificity	Expressed at high levels in spleen, thymus and leukocytes. Also expressed in lung and placenta, and at very low levels in brain, heart, skeletal muscle and kidney. Expressed in cytotoxic T-lymphocytes (CTL) and mast cells. {ECO:0000269|PubMed:14622600, ECO:0000269|PubMed:15548590}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

UNC13D 293T Cell Transient Overexpression Lysate(Denatured) - H00201294-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

UNC13D overexpression lysate - LY403710 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

UNC13D 293 Cell Lysate - 403196 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg Species C. elegans

UNC13D/Munc 13-4 Overexpression Lysate (Denatured) - H00201294-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

UNC13D/Munc 13-4 Overexpression Lysate (Native) - NBL1-17611 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Munc13-4 (h): 293T Lysate - sc-177578 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

UNC13D Over-expression Lysate Product - GWB-10E35A from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

UNC13D/Munc 13-4 Overexpression Lysate (Denatured) - H00201294-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Panoply™ Human UNC13D Knockdown Stable Cell Line - CSC-DC017087 from Creative biogene Category Cell Line Species Human

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