| Gene Symbol |
CATSPER4
|
| Entrez Gene |
378807
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cation channel, sperm associated 4
|
| Other Description |
cation channel sperm-associated protein 4|ion channel CatSper4
|
| Swissprots |
Q7RTX7 Q5VY71 A1A4W6
|
| Accessions |
EAX07839 Q7RTX7 BC128138 AAI28139 BC128139 AAI28140 BC144663 BN000273 CAE30475 XM_011541432 XP_011539734 XM_011541433 XP_011539735 NM_198137 NP_937770
|
| Function |
Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH. {ECO:0000269|PubMed:21412338, ECO:0000269|PubMed:21412339}.
|
| Subcellular Location |
Cell projection, cilium, flagellum membrane; Multi-pass membrane protein. Note=Specifically located in the principal piece of sperm tail.
|
| Tissue Specificity |
Testis-specific. {ECO:0000269|PubMed:12932298, ECO:0000269|PubMed:17347248}.
|