CATSPER4

Gene Symbol CATSPER4
Entrez Gene 378807
Alt Symbol -
Species Human
Gene Type protein-coding
Description cation channel, sperm associated 4
Other Description cation channel sperm-associated protein 4|ion channel CatSper4
Swissprots Q7RTX7 Q5VY71 A1A4W6
Accessions EAX07839 Q7RTX7 BC128138 AAI28139 BC128139 AAI28140 BC144663 BN000273 CAE30475 XM_011541432 XP_011539734 XM_011541433 XP_011539735 NM_198137 NP_937770
Function Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH. {ECO:0000269|PubMed:21412338, ECO:0000269|PubMed:21412339}.
Subcellular Location Cell projection, cilium, flagellum membrane; Multi-pass membrane protein. Note=Specifically located in the principal piece of sperm tail.
Tissue Specificity Testis-specific. {ECO:0000269|PubMed:12932298, ECO:0000269|PubMed:17347248}.

CatSper4 CRISPR/Cas9 KO Plasmid (h) - sc-415725 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CatSper4 HDR Plasmid (h) - sc-415725-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CatSper4 Double Nickase Plasmid (h) - sc-415725-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CatSper4 Double Nickase Plasmid (h2) - sc-415725-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CatSper4 CRISPR Activation Plasmid (h) - sc-415725-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CatSper4 CRISPR Activation Plasmid (h2) - sc-415725-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CatSper4 Lentiviral Activation Particles (h) - sc-415725-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CatSper4 Lentiviral Activation Particles (h2) - sc-415725-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CatSper4 siRNA (h) - sc-72813 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CatSper4 shRNA Plasmid (h) - sc-72813-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CatSper4 shRNA (h) Lentiviral Particles - sc-72813-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CATSPER4 RNAi - H00378807-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN5399 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5399 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

CATSPER4 siRNA (Human) - CRJ7699 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CATSPER4 - MBS8212108 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human Catsper4 (NM_198137.1) - SHH255177 from Creative biogene

Category siRNA
Species Reactivities Human

Human CATSPER4 siRNA - orb278200 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CATSPER4 shRNA Plasmid (Human) - CHJ7699 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

CATSPER4 miRNA 3'UTR clone - MiUTR1H-01696 from Creative biogene

Species Reactivities Human
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