KCNMB4

Gene Symbol	KCNMB4
Entrez Gene	27345
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	potassium channel subfamily M regulatory beta subunit 4
Other Description	BK channel beta subunit 4|BK channel subunit beta-4|BKbeta4|MaxiK channel beta-subunit 4|big potassium channel beta subunit 4|calcium-activated potassium channel subunit beta-4|calcium-activated potassium channel, subfamily M subunit beta-4|charybdotoxin receptor subunit beta-4|hbeta4|k(VCA)beta-4|large conductance calcium-dependent potassium ion channel beta 4 subunit|maxi K channel subunit beta-4|potassium large conductance calcium-activated channel, subfamily M, beta member 4|slo-beta-4
Swissprots	Q9P0G5 Q9NPA4 Q86W47 Q8IVR3
Accessions	CAB70439 EAW97251 Q86W47 AF160967 AAF69805 AF207992 AAF28333 AF215891 AAF75596 AK054684 BC037898 BC042446 AAH42446 BC047427 BC050621 AAH50621 BM805224 BU556960 XM_011538188 XP_011536490 XR_245917 NM_014505 NP_055320
Function	Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations. {ECO:0000269|PubMed:10692449, ECO:0000269|PubMed:10792058, ECO:0000269|PubMed:10828459}.
Subcellular Location	Membrane; Multi-pass membrane protein.
Tissue Specificity	Predominantly expressed in brain. In brain, it is expressed in the cerebellum, cerebral cortex, medulla, spinal cord, occipital pole, frontal lobe, temporal lobe, putamen, amygdala, caudate nucleus, corpus callosum, hippocampus, substantia nigra and thalamus. Weakly or not expressed in other tissues. {ECO:0000269|PubMed:10692449, ECO:0000269|PubMed:10828459}.
Top Pathways	Vascular smooth muscle contraction, cGMP-PKG signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

KCNMB4 (H-71) - sc-368061 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

KCNMB4 (K-14) - sc-161767 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

KCNMB4 (Q-14) - sc-161769 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-KCNMB4 antibody - ab89703 from Abcam Prices $370.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-KCNMB4 antibody - ab172515 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-KCNMB4 antibody - ab57278 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-KCNMB4 antibody [S18A-3] - ab105587 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone S18A-3

Anti-KCNMB4 Antibody (aa45-167, clone S18A-3, Atto 488) - LS-C228438 from LifeSpan Bioscience Host Mouse Clonality Monoclonal Clone S18A-3

Anti-KCNMB4 Antibody (aa45-167, clone S18A-3, Atto 390) - LS-C228437 from LifeSpan Bioscience Host Mouse Clonality Monoclonal Clone S18A-3

Anti-KCNMB4 Antibody (aa45-167, clone S18A-3, Atto 594) - LS-C228440 from LifeSpan Bioscience Host Mouse Clonality Monoclonal Clone S18A-3

Anti-KCNMB4 Antibody (aa45-167, clone S18A-3, Atto 633) - LS-C228441 from LifeSpan Bioscience Host Mouse Clonality Monoclonal Clone S18A-3

Anti-KCNMB4 Antibody (aa45-167, clone S18A-3, Atto 565) - LS-C228439 from LifeSpan Bioscience Host Mouse Clonality Monoclonal Clone S18A-3

Anti-KCNMB4 Antibody (aa45-167, clone S18A-3, Atto 680) - LS-C228443 from LifeSpan Bioscience Host Mouse Clonality Monoclonal Clone S18A-3

Anti-KCNMB4 Antibody (aa45-167, clone S18A-3, Atto 655) - LS-C228442 from LifeSpan Bioscience Host Mouse Clonality Monoclonal Clone S18A-3

Anti-KCNMB4 Antibody (aa45-167, clone S18A-3, FITC) - LS-C228445 from LifeSpan Bioscience Host Mouse Clonality Monoclonal Clone S18A-3

Anti-KCNMB4 Antibody (aa45-167, clone S18A-3, Atto 700) - LS-C228444 from LifeSpan Bioscience Host Mouse Clonality Monoclonal Clone S18A-3

Anti-KCNMB4 Antibody (aa45-167, clone S18A-3, RPE) - LS-C228450 from LifeSpan Bioscience Host Mouse Clonality Monoclonal Clone S18A-3

Anti-KCNMB4 Antibody (aa45-167, clone S18A-3, PE-Atto 594) - LS-C228447 from LifeSpan Bioscience Host Mouse Clonality Monoclonal Clone S18A-3

Anti-KCNMB4 Antibody (aa45-167, clone S18A-3, SA) - LS-C228449 from LifeSpan Bioscience Host Mouse Clonality Monoclonal Clone S18A-3

Anti-KCNMB4 Antibody (aa45-167, clone S18A-3, APC) - LS-C229959 from LifeSpan Bioscience Host Mouse Clonality Monoclonal Clone S18A-3

Anti-KCNMB4 Antibody (aa45-167, clone S18A-3, AP) - LS-C229957 from LifeSpan Bioscience Host Mouse Clonality Monoclonal Clone S18A-3

Anti-KCNMB4 Antibody (aa45-167, clone S18A-3, PerCP) - LS-C228448 from LifeSpan Bioscience Host Mouse Clonality Monoclonal Clone S18A-3

Anti-KCNMB4 Antibody (aa45-167, clone S18A-3, Biotin) - LS-C229960 from LifeSpan Bioscience Host Mouse Clonality Monoclonal Clone S18A-3

Anti-KCNMB4 Antibody (clone S18A-3) - LS-C150436 from LifeSpan Bioscience Host Mouse Clonality Monoclonal Clone S18A-3

Anti-KCNMB4 Antibody (aa71-120) - LS-C110010 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

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