| Gene Symbol |
KCNMB4
|
| Entrez Gene |
27345
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
potassium channel subfamily M regulatory beta subunit 4
|
| Other Description |
BK channel beta subunit 4|BK channel subunit beta-4|BKbeta4|MaxiK channel beta-subunit 4|big potassium channel beta subunit 4|calcium-activated potassium channel subunit beta-4|calcium-activated potassium channel, subfamily M subunit beta-4|charybdotoxin receptor subunit beta-4|hbeta4|k(VCA)beta-4|large conductance calcium-dependent potassium ion channel beta 4 subunit|maxi K channel subunit beta-4|potassium large conductance calcium-activated channel, subfamily M, beta member 4|slo-beta-4
|
| Swissprots |
Q9P0G5 Q9NPA4 Q86W47 Q8IVR3
|
| Accessions |
CAB70439 EAW97251 Q86W47 AF160967 AAF69805 AF207992 AAF28333 AF215891 AAF75596 AK054684 BC037898 BC042446 AAH42446 BC047427 BC050621 AAH50621 BM805224 BU556960 XM_011538188 XP_011536490 XR_245917 NM_014505 NP_055320
|
| Function |
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations. {ECO:0000269|PubMed:10692449, ECO:0000269|PubMed:10792058, ECO:0000269|PubMed:10828459}.
|
| Subcellular Location |
Membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Predominantly expressed in brain. In brain, it is expressed in the cerebellum, cerebral cortex, medulla, spinal cord, occipital pole, frontal lobe, temporal lobe, putamen, amygdala, caudate nucleus, corpus callosum, hippocampus, substantia nigra and thalamus. Weakly or not expressed in other tissues. {ECO:0000269|PubMed:10692449, ECO:0000269|PubMed:10828459}.
|
| Top Pathways |
Vascular smooth muscle contraction, cGMP-PKG signaling pathway
|
![Western Blot: KCNMB4 Overexpression Lysate (Adult Normal) [NBL1-12193] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for KCNMB4.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8603_KCNMB4%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12193-img0002.jpg)