KCNMB4

Gene Symbol KCNMB4
Entrez Gene 27345
Alt Symbol -
Species Human
Gene Type protein-coding
Description potassium channel subfamily M regulatory beta subunit 4
Other Description BK channel beta subunit 4|BK channel subunit beta-4|BKbeta4|MaxiK channel beta-subunit 4|big potassium channel beta subunit 4|calcium-activated potassium channel subunit beta-4|calcium-activated potassium channel, subfamily M subunit beta-4|charybdotoxin receptor subunit beta-4|hbeta4|k(VCA)beta-4|large conductance calcium-dependent potassium ion channel beta 4 subunit|maxi K channel subunit beta-4|potassium large conductance calcium-activated channel, subfamily M, beta member 4|slo-beta-4
Swissprots Q9P0G5 Q9NPA4 Q86W47 Q8IVR3
Accessions CAB70439 EAW97251 Q86W47 AF160967 AAF69805 AF207992 AAF28333 AF215891 AAF75596 AK054684 BC037898 BC042446 AAH42446 BC047427 BC050621 AAH50621 BM805224 BU556960 XM_011538188 XP_011536490 XR_245917 NM_014505 NP_055320
Function Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations. {ECO:0000269|PubMed:10692449, ECO:0000269|PubMed:10792058, ECO:0000269|PubMed:10828459}.
Subcellular Location Membrane; Multi-pass membrane protein.
Tissue Specificity Predominantly expressed in brain. In brain, it is expressed in the cerebellum, cerebral cortex, medulla, spinal cord, occipital pole, frontal lobe, temporal lobe, putamen, amygdala, caudate nucleus, corpus callosum, hippocampus, substantia nigra and thalamus. Weakly or not expressed in other tissues. {ECO:0000269|PubMed:10692449, ECO:0000269|PubMed:10828459}.
Top Pathways Vascular smooth muscle contraction, cGMP-PKG signaling pathway

KCNMB4 CRISPR/Cas9 KO Plasmid (h) - sc-405044 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCNMB4 HDR Plasmid (h) - sc-405044-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCNMB4 Double Nickase Plasmid (h) - sc-405044-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCNMB4 Double Nickase Plasmid (h2) - sc-405044-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCNMB4 CRISPR Activation Plasmid (h) - sc-405044-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCNMB4 CRISPR Activation Plasmid (h2) - sc-405044-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCNMB4 Lentiviral Activation Particles (h) - sc-405044-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCNMB4 Lentiviral Activation Particles (h2) - sc-405044-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCNMB4 siRNA (h) - sc-96190 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

KCNMB4 shRNA Plasmid (h) - sc-96190-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

KCNMB4 shRNA (h) Lentiviral Particles - sc-96190-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

KCNMB4 RNAi - H00027345-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU153611 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN10980 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10980 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05347 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr05347

KCNMB4 siRNA (Human) - CRH9094 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human KCNMB4 (NM_014505.5) - SHH323575 from Creative biogene

Category siRNA
Species Reactivities Human

Human KCNMB4 siRNA - orb269596 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

KCNMB4 shRNA Plasmid (Human) - CHH9094 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

KCNMB4 miRNA 3'UTR clone - MiUTR3H-07492 from Creative biogene

Species Reactivities Human
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