RNF19A

Gene Symbol	RNF19A
Entrez Gene	25897
Alt Symbol	RNF19
Species	Human
Gene Type	protein-coding
Description	ring finger protein 19A, RBR E3 ubiquitin protein ligase
Other Description	E3 ubiquitin-protein ligase RNF19A|double ring-finger protein|protein p38 interacting with transcription factor Sp1|ring finger protein 19|ring finger protein 19A, E3 ubiquitin protein ligase|ring-IBR-ring domain containing protein Dorfin
Swissprots	Q9UFG0 Q9NV58 Q9H8M8 Q9UFX6 Q9H5H9 Q52LG1 A3KCU9 Q9Y4Y1
Accessions	EAW91807 Q9NV58 AB029316 BAB39353 AB271913 BAF48116 AB271914 BAF48117 AJ242975 CAB45132 AK023455 BAB14581 AK027070 BAB15647 AK057699 AL110253 CAB53700 AL122096 CAB59264 AL708565 BC043648 AAH43648 BC062676 BC093938 AAH93938 BC093940 AAH93940 BC105300 AAI05301 BQ003778 DA502897 DB037264 DB061830 XM_005250853 XP_005250910 XM_011516956 XP_011515258 XR_928315 XR_928316 NM_001280539 NP_001267468 NM_015435 NP_056250 NM_183419 NP_904355
Function	E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection. {ECO:0000269|PubMed:11237715, ECO:0000269|PubMed:12145308, ECO:0000269|PubMed:12750386, ECO:0000269|PubMed:15456787, ECO:0000269|PubMed:16513638}.
Subcellular Location	Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:11237715, ECO:0000269|PubMed:12145308, ECO:0000269|PubMed:12750386, ECO:0000269|PubMed:15456787}. Note=Present in the hyaline inclusion bodies specifically found in motor neurons from amyotrophic lateral sclerosis patients. Present in the Lewy bodies specifically found in neurons from Parkinson disease patients.
Tissue Specificity	Widely expressed, with highest levels in heart. Ubiquitously expressed in the central nervous system. {ECO:0000269|PubMed:11237715}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human DORFIN protein fragment - ab161828 from Abcam Category Protein Source Wheat germ Species Human

RNF19A / DORFIN Antibody Blocking Peptide - LS-E3093 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RNF19A / DORFIN Antibody Blocking Peptide - LS-E25444 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RNF19A / DORFIN Antibody Blocking Peptide - LS-E15899 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human DORFIN Protein - H00025897-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

RNF19A-Antibody-Center-Blocking-Peptide - BP14232c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DORFIN/RNF19 blocking peptide - GTX89864-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Dog, Pig, Bovine

RNF19A Blocking Peptide - 33R-3962 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Dorfin Peptide - AC21-0273-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

RNF19A / RNF19 - H00025897-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RNF19A / RNF19 - H00025897-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

DORFIN Peptide - 45-493P from ProSci Category Peptide Prices $175.00 Sizes 100 µg

RNF19A fusion protein - ag12633 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

DORFIN/RNF19, Peptide - MBS426463 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Dog, Pig, Bovine

DORFIN Recombinant Protein Antigen - NBP1-87989PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

RNF19A Peptide, Human - M34GP13412H from Creative Peptides Category Peptide Source Synthetic. Species Human

RNF19A Immunizing peptide - orb17302 from Biorbyt Category Peptide

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