RNF19A

Gene Symbol	RNF19A
Entrez Gene	25897
Alt Symbol	RNF19
Species	Human
Gene Type	protein-coding
Description	ring finger protein 19A, RBR E3 ubiquitin protein ligase
Other Description	E3 ubiquitin-protein ligase RNF19A|double ring-finger protein|protein p38 interacting with transcription factor Sp1|ring finger protein 19|ring finger protein 19A, E3 ubiquitin protein ligase|ring-IBR-ring domain containing protein Dorfin
Swissprots	Q9UFG0 Q9NV58 Q9H8M8 Q9UFX6 Q9H5H9 Q52LG1 A3KCU9 Q9Y4Y1
Accessions	EAW91807 Q9NV58 AB029316 BAB39353 AB271913 BAF48116 AB271914 BAF48117 AJ242975 CAB45132 AK023455 BAB14581 AK027070 BAB15647 AK057699 AL110253 CAB53700 AL122096 CAB59264 AL708565 BC043648 AAH43648 BC062676 BC093938 AAH93938 BC093940 AAH93940 BC105300 AAI05301 BQ003778 DA502897 DB037264 DB061830 XM_005250853 XP_005250910 XM_011516956 XP_011515258 XR_928315 XR_928316 NM_001280539 NP_001267468 NM_015435 NP_056250 NM_183419 NP_904355
Function	E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection. {ECO:0000269|PubMed:11237715, ECO:0000269|PubMed:12145308, ECO:0000269|PubMed:12750386, ECO:0000269|PubMed:15456787, ECO:0000269|PubMed:16513638}.
Subcellular Location	Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:11237715, ECO:0000269|PubMed:12145308, ECO:0000269|PubMed:12750386, ECO:0000269|PubMed:15456787}. Note=Present in the hyaline inclusion bodies specifically found in motor neurons from amyotrophic lateral sclerosis patients. Present in the Lewy bodies specifically found in neurons from Parkinson disease patients.
Tissue Specificity	Widely expressed, with highest levels in heart. Ubiquitously expressed in the central nervous system. {ECO:0000269|PubMed:11237715}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Dorfin (C-19) - sc-55808 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Dorfin (H-133) - sc-366373 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Dorfin (N-20) - sc-55810 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-DORFIN antibody - ab123343 from Abcam Prices $359.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-DORFIN antibody - ab57146 from Abcam Host Mouse Clonality Monoclonal

Anti-DORFIN antibody - Aminoterminal end - ab67285 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-RNF19A / DORFIN Antibody (aa795-807) - LS-C54734 from LifeSpan Bioscience Prices $335.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-RNF19A / DORFIN Antibody (aa384-413, AP) - LS-C240127 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RNF19A / DORFIN Antibody (aa384-413, APC) - LS-C240128 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RNF19A / DORFIN Antibody (aa384-413, Biotin) - LS-C240129 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RNF19A / DORFIN Antibody (aa36-85) - LS-C200608 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-RNF19A / DORFIN Antibody (aa384-413, PE) - LS-C240131 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RNF19A / DORFIN Antibody (aa384-413, Azide-free, HRP) - LS-C248027 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RNF19A / DORFIN Antibody (aa51-100) - LS-C291327 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-RNF19A / DORFIN Antibody (aa383-413) - LS-C324736 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RNF19A / DORFIN Antibody (aa108-157) - LS-C102006 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-RNF19A / DORFIN Antibody (aa600-650) - LS-C289806 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-RNF19A / DORFIN Antibody (aa384-413) - LS-C162653 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-RNF19A / DORFIN Antibody (aa384-413, FITC) - LS-C240130 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

DORFIN Antibody - NBP1-59367 from Novus Biologicals Prices $369.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

DORFIN Antibody - NBP1-87989 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

DORFIN Antibody - NBP1-71860 from Novus Biologicals Prices $359.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

DORFIN Antibody - NB300-873 from Novus Biologicals Prices $229.00 Sizes 100 µg Host Goat Clonality Polyclonal

DORFIN Antibody (4E4) - H00025897-M01A from Novus Biologicals Prices $349.00 Sizes 200 µl Host Mouse Clonality Monoclonal Clone 4E4

DORFIN Antibody - H00025897-A01 from Novus Biologicals Prices $269.00 Sizes 50 µl Host Mouse Clonality Polyclonal

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