| Gene Symbol |
HTR1E
|
| Entrez Gene |
3354
|
| Alt Symbol |
5-HT1E
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
|
| Other Description |
5-HT-1E|5-hydroxytryptamine receptor 1E|S31|serotonin receptor 1E
|
| Swissprots |
E1P503 P28566 Q9P1Y1
|
| Accessions |
AAA58355 BAA94458 CAA77558 EAW48616 EAW48617 P28566 AF498980 AAM21127 AL521170 BC069751 AAH69751 M91467 AAA58353 XM_011535789 XP_011534091 XM_011535790 XP_011534092 NM_000865 NP_000856
|
| Function |
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. {ECO:0000269|PubMed:14744596, ECO:0000269|PubMed:1513320, ECO:0000269|PubMed:1608964, ECO:0000269|PubMed:1733778, ECO:0000269|PubMed:21422162}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:14744596, ECO:0000269|PubMed:1513320, ECO:0000269|PubMed:1608964, ECO:0000269|PubMed:1733778, ECO:0000269|PubMed:21422162}; Multi- pass membrane protein {ECO:0000269|PubMed:14744596, ECO:0000269|PubMed:1513320, ECO:0000269|PubMed:1608964, ECO:0000269|PubMed:1733778, ECO:0000269|PubMed:21422162}.
|
| Tissue Specificity |
Detected in brain. {ECO:0000269|PubMed:14744596}.
|
| Top Pathways |
cAMP signaling pathway, Neuroactive ligand-receptor interaction
|