Gene Symbol | HTR1E |
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Entrez Gene | 3354 |
Alt Symbol | 5-HT1E |
Species | Human |
Gene Type | protein-coding |
Description | 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled |
Other Description | 5-HT-1E|5-hydroxytryptamine receptor 1E|S31|serotonin receptor 1E |
Swissprots | E1P503 P28566 Q9P1Y1 |
Accessions | AAA58355 BAA94458 CAA77558 EAW48616 EAW48617 P28566 AF498980 AAM21127 AL521170 BC069751 AAH69751 M91467 AAA58353 XM_011535789 XP_011534091 XM_011535790 XP_011534092 NM_000865 NP_000856 |
Function | G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. {ECO:0000269|PubMed:14744596, ECO:0000269|PubMed:1513320, ECO:0000269|PubMed:1608964, ECO:0000269|PubMed:1733778, ECO:0000269|PubMed:21422162}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:14744596, ECO:0000269|PubMed:1513320, ECO:0000269|PubMed:1608964, ECO:0000269|PubMed:1733778, ECO:0000269|PubMed:21422162}; Multi- pass membrane protein {ECO:0000269|PubMed:14744596, ECO:0000269|PubMed:1513320, ECO:0000269|PubMed:1608964, ECO:0000269|PubMed:1733778, ECO:0000269|PubMed:21422162}. |
Tissue Specificity | Detected in brain. {ECO:0000269|PubMed:14744596}. |
Top Pathways | cAMP signaling pathway, Neuroactive ligand-receptor interaction |
Human 5HT1E Receptor full length protein - ab158713 from Abcam
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Human 5HT1E Receptor protein fragment - ab158714 from Abcam
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HTR1E / 5-HT1E Receptor Antibody Blocking Peptide - LS-E28616 from LifeSpan Bioscience
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HTR1E / 5-HT1E Receptor Antibody Blocking Peptide - LS-E28617 from LifeSpan Bioscience
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HTR1E / 5-HT1E Receptor Antibody Blocking Peptide - LS-E29128 from LifeSpan Bioscience
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Recombinant Human 5-HT1E Protein - H00003354-Q01 from Novus Biologicals
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5-HT1E Recombinant Protein - H00003354-P01 from Novus Biologicals
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Serotonin receptor 1E (HTR1E) - H00003354-G01 from Acris Antibodies
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Serotonin receptor 1E (HTR1E) - H00003354-P01-02 from Acris Antibodies
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Serotonin receptor 1E (HTR1E) - H00003354-Q01-10 from Acris Antibodies
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Serotonin receptor 1E (HTR1E) - H00003354-Q01-25 from Acris Antibodies
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SR-1E (A127) Peptide - BS2386P from Bioworld Technology
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Recombinant Human 5-HT1E Protein - H00003354-G01 from Novus Biologicals
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5-hydroxytryptamine receptor 1E (HTR1E), Recombinant Protein - MBS962884 from MyBioSource
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5-HT1E Recombinant Protein Antigen - NBP1-90320PEP from Novus Biologicals
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HTR1E-Blocking-Peptide-C-Term - BP21709b from Abgent, a WuXi AppTec company
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HTR1E Peptide, Human - M34GP07340H from Creative Peptides
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5-hydroxytryptamine receptor 1E (HTR1E), Recombinant Protein - MBS7017274 from MyBioSource
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5-hydroxytryptamine receptor 1E (HTR1E), Recombinant Protein - MBS7017275 from MyBioSource
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