Gene Symbol | HTR1E |
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Entrez Gene | 3354 |
Alt Symbol | 5-HT1E |
Species | Human |
Gene Type | protein-coding |
Description | 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled |
Other Description | 5-HT-1E|5-hydroxytryptamine receptor 1E|S31|serotonin receptor 1E |
Swissprots | E1P503 P28566 Q9P1Y1 |
Accessions | AAA58355 BAA94458 CAA77558 EAW48616 EAW48617 P28566 AF498980 AAM21127 AL521170 BC069751 AAH69751 M91467 AAA58353 XM_011535789 XP_011534091 XM_011535790 XP_011534092 NM_000865 NP_000856 |
Function | G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. {ECO:0000269|PubMed:14744596, ECO:0000269|PubMed:1513320, ECO:0000269|PubMed:1608964, ECO:0000269|PubMed:1733778, ECO:0000269|PubMed:21422162}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:14744596, ECO:0000269|PubMed:1513320, ECO:0000269|PubMed:1608964, ECO:0000269|PubMed:1733778, ECO:0000269|PubMed:21422162}; Multi- pass membrane protein {ECO:0000269|PubMed:14744596, ECO:0000269|PubMed:1513320, ECO:0000269|PubMed:1608964, ECO:0000269|PubMed:1733778, ECO:0000269|PubMed:21422162}. |
Tissue Specificity | Detected in brain. {ECO:0000269|PubMed:14744596}. |
Top Pathways | cAMP signaling pathway, Neuroactive ligand-receptor interaction |
SR-1E (D-9) - sc-390170 from Santa Cruz Biotechnology
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SR-1E (A-18) - sc-32544 from Santa Cruz Biotechnology
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SR-1E (C-19) - sc-1465 from Santa Cruz Biotechnology
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SR-1E (H-80) - sc-25645 from Santa Cruz Biotechnology
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Anti-5HT1E Receptor antibody - ab115294 from Abcam
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Anti-5HT1E Receptor antibody - ab69594 from Abcam
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Anti-5HT1E Receptor antibody [EPR10789(B)] - ab154813 from Abcam
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Anti-5HT1E Receptor antibody - Cytoplasmic domain - ab140506 from Abcam
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Anti-HTR1E / 5-HT1E Receptor Antibody (clone 2E9) - LS-C197472 from LifeSpan Bioscience
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Anti-HTR1E / 5-HT1E Receptor Antibody (Ala127) - LS-C176959 from LifeSpan Bioscience
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Anti-HTR1E / 5-HT1E Receptor Antibody (aa101-150) - LS-C119366 from LifeSpan Bioscience
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Anti-HTR1E / 5-HT1E Receptor Antibody (N-Terminus) - LS-C201218 from LifeSpan Bioscience
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Anti-HTR1E / 5-HT1E Receptor Antibody (Cytoplasmic Domain) IHC-plus⢠- LS-A6374 from LifeSpan Bioscience
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Anti-HTR1E / 5-HT1E Receptor Antibody (Cytoplasmic Domain) IHC-plus⢠- LS-A2738 from LifeSpan Bioscience
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Anti-HTR1E / 5-HT1E Receptor Antibody (Cytoplasmic Domain) IHC-plus⢠- LS-A2739 from LifeSpan Bioscience
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5-HT1E Antibody - NBP1-90320 from Novus Biologicals
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5-HT1E Antibody - NBP1-46597 from Novus Biologicals
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5-HT1E Antibody - NBP1-02660 from Novus Biologicals
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5-HT1E Antibody - NBP1-19624 from Novus Biologicals
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5-HT1E Antibody - H00003354-B01 from Novus Biologicals
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5-HT1E Antibody (2E9.) - H00003354-M03 from Novus Biologicals
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Monoclonal Anti-HTR1E antibody produced in mouse - SAB1401189 from Sigma-Aldrich
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Anti-HTR1E antibody produced in rabbit - HPA004931 from Sigma-Aldrich
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Anti-5-HT-1E antibody produced in rabbit - SAB4501472 from Sigma-Aldrich
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HTR1E Antibody - N-terminal region (ARP30713_T100) - ARP30713_T100 from Aviva Systems Biology
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