KCNQ2

Gene Symbol	KCNQ2
Entrez Gene	3785
Alt Symbol	BFNC, BFNS1, EBN, EBN1, EIEE7, ENB1, HNSPC, KCNA11, KV7.2, KVEBN1
Species	Human
Gene Type	protein-coding
Description	potassium channel, voltage gated KQT-like subfamily Q, member 2
Other Description	KQT-like 2|neuroblastoma-specific potassium channel protein|neuroblastoma-specific potassium channel subunit alpha KvLQT2|potassium voltage-gated channel subfamily KQT member 2|potassium voltage-gated channel, KQT-like subfamily, member 2|voltage-gated potassium channel subunit Kv7.2
Swissprots	Q4VXR6 Q96J59 O95845 Q5VYT8 O75580 O43526 Q4VXP4 Q99454 O43796
Accessions	EAW75271 EAW75272 EAW75273 EAW75274 EAW75275 EAW75276 EAW75277 EAW75278 EAW75279 EAW75280 EAW75281 EAW75282 O43526 AF033348 AAB97315 AF074247 AAC25921 AF110020 AAD16988 AK293727 BAG57155 AY358189 AAQ88556 BC000699 AAH00699 BC020384 BC127262 BC146294 AAI46295 BT007043 AAP35692 D82346 BAA11557 Y15065 CAA75348 XM_006723787 XP_006723850 XM_011528807 XP_011527109 XM_011528808 XP_011527110 XM_011528809 XP_011527111 XM_011528810 XP_011527112 XM_011528811 XP_011527113 XM_011528812 XP_011527114 XM_011528813 XP_011527115 XM_011528814 XP_011527116 XM_011528815 XP_011527117 XM_011528816 XP_011527118 NM_004518 NP_004509 NM_172106 NP_742104 NM_172107 NP_742105 NM_172108 NP_742106 NM_172109 NP_742107
Function	Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. KCNQ2/KCNQ3 current is blocked by linopirdine and XE991, and activated by the anticonvulsant retigabine. Muscarinic agonist oxotremorine-M strongly suppress KCNQ2/KCNQ3 current in cells in which cloned KCNQ2/KCNQ3 channels were coexpressed with M1 muscarinic receptors.
Subcellular Location	Membrane; Multi-pass membrane protein.
Tissue Specificity	In adult and fetal brain. Highly expressed in areas containing neuronal cell bodies, low in spinal chord and corpus callosum. Isoform 2 is preferentially expressed in differentiated neurons. Isoform 6 is prominent in fetal brain, undifferentiated neuroblastoma cells and brain tumors. {ECO:0000269|PubMed:10781098}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human KCNQ2 full length protein - ab132148 from Abcam Category Protein Source Wheat germ Species Human

Human KCNQ2 peptide - ab25449 from Abcam Category Peptide

KCNQ2 Antibody Blocking Peptide - LS-E12609 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KCNQ2 Antibody Blocking Peptide - LS-E12608 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KCNQ2 Antibody Blocking Peptide - LS-E12610 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KCNQ2 Antibody Blocking Peptide - LS-E12498 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Kv7.2 Protein - H00003785-P01 from Novus Biologicals Category Protein Prices $250.00 Sizes 2 µg Species Human

KCNQ2 Blocking Peptide - 33R-3461 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Kcnq2 Blocking Peptide - 33R-10425 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

KCNQ2 Blocking Peptide - 33R-8523 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

KCNQ2 Blocking Peptide - 33R-3916 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

KCNQ2 Blocking Peptide - 33R-10224 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

KCNQ2 - H00003785-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

KCNQ2 fusion protein - ag13912 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

KCNQ2 fusion protein - Ag14036 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Potassium voltage-gated channel subfamily KQT member 2 (KCNQ2), Recombinant Protein - MBS1225997 from MyBioSource Category Protein Prices $1,375.00, $1,835.00 Sizes 1 mg (E-Coli), 1 mg (Yeast) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Kv7.2 Recombinant Protein Antigen - NBP1-88645PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Kv7.2 Recombinant Protein Antigen - NBP2-38820PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

KCNQ2 Peptide, Human - M34GP08000H from Creative Peptides Category Peptide Source Synthetic. Species Human

KCNQ2 fusion protein - Ag25781 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

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