KCNQ2

Gene Symbol KCNQ2
Entrez Gene 3785
Alt Symbol BFNC, BFNS1, EBN, EBN1, EIEE7, ENB1, HNSPC, KCNA11, KV7.2, KVEBN1
Species Human
Gene Type protein-coding
Description potassium channel, voltage gated KQT-like subfamily Q, member 2
Other Description KQT-like 2|neuroblastoma-specific potassium channel protein|neuroblastoma-specific potassium channel subunit alpha KvLQT2|potassium voltage-gated channel subfamily KQT member 2|potassium voltage-gated channel, KQT-like subfamily, member 2|voltage-gated potassium channel subunit Kv7.2
Swissprots Q4VXR6 Q96J59 O95845 Q5VYT8 O75580 O43526 Q4VXP4 Q99454 O43796
Accessions EAW75271 EAW75272 EAW75273 EAW75274 EAW75275 EAW75276 EAW75277 EAW75278 EAW75279 EAW75280 EAW75281 EAW75282 O43526 AF033348 AAB97315 AF074247 AAC25921 AF110020 AAD16988 AK293727 BAG57155 AY358189 AAQ88556 BC000699 AAH00699 BC020384 BC127262 BC146294 AAI46295 BT007043 AAP35692 D82346 BAA11557 Y15065 CAA75348 XM_006723787 XP_006723850 XM_011528807 XP_011527109 XM_011528808 XP_011527110 XM_011528809 XP_011527111 XM_011528810 XP_011527112 XM_011528811 XP_011527113 XM_011528812 XP_011527114 XM_011528813 XP_011527115 XM_011528814 XP_011527116 XM_011528815 XP_011527117 XM_011528816 XP_011527118 NM_004518 NP_004509 NM_172106 NP_742104 NM_172107 NP_742105 NM_172108 NP_742106 NM_172109 NP_742107
Function Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. KCNQ2/KCNQ3 current is blocked by linopirdine and XE991, and activated by the anticonvulsant retigabine. Muscarinic agonist oxotremorine-M strongly suppress KCNQ2/KCNQ3 current in cells in which cloned KCNQ2/KCNQ3 channels were coexpressed with M1 muscarinic receptors.
Subcellular Location Membrane; Multi-pass membrane protein.
Tissue Specificity In adult and fetal brain. Highly expressed in areas containing neuronal cell bodies, low in spinal chord and corpus callosum. Isoform 2 is preferentially expressed in differentiated neurons. Isoform 6 is prominent in fetal brain, undifferentiated neuroblastoma cells and brain tumors. {ECO:0000269|PubMed:10781098}.

KCNQ2 CRISPR/Cas9 KO Plasmid (h) - sc-402492 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCNQ2 HDR Plasmid (h) - sc-402492-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCNQ2 Double Nickase Plasmid (h) - sc-402492-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCNQ2 Double Nickase Plasmid (h2) - sc-402492-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCNQ2 CRISPR Activation Plasmid (h) - sc-402492-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCNQ2 CRISPR Activation Plasmid (h2) - sc-402492-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCNQ2 Lentiviral Activation Particles (h) - sc-402492-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCNQ2 Lentiviral Activation Particles (h2) - sc-402492-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCNQ2 siRNA (h) - sc-35747 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

KCNQ2 shRNA Plasmid (h) - sc-35747-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

KCNQ2 shRNA (h) Lentiviral Particles - sc-35747-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Kv7.2 RNAi - H00003785-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Kv7.2 RNAi - H00003785-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Kv7.2 RNAi - H00003785-R04 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Kv7.2 RNAi - H00003785-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU124741 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN2552 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2552 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05261 from Sigma-Aldrich

Category miRNA

KCNQ2 siRNA (Human) - CRH2559 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Kv7.2 RNAi - H00003785-R05 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

shRNA set against Human KCNQ2 (NM_004518.4) - SHH323655 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human KCNQ2(NM_172107.2) - SHL192126 from Creative biogene

Category siRNA
Species Reactivities Human

Human KCNQ2 siRNA - orb263061 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

KCNQ2 shRNA Plasmid (Human) - CHH2559 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
Search more