KCNQ2

Gene Symbol KCNQ2
Entrez Gene 3785
Alt Symbol BFNC, BFNS1, EBN, EBN1, EIEE7, ENB1, HNSPC, KCNA11, KV7.2, KVEBN1
Species Human
Gene Type protein-coding
Description potassium channel, voltage gated KQT-like subfamily Q, member 2
Other Description KQT-like 2|neuroblastoma-specific potassium channel protein|neuroblastoma-specific potassium channel subunit alpha KvLQT2|potassium voltage-gated channel subfamily KQT member 2|potassium voltage-gated channel, KQT-like subfamily, member 2|voltage-gated potassium channel subunit Kv7.2
Swissprots Q4VXR6 Q96J59 O95845 Q5VYT8 O75580 O43526 Q4VXP4 Q99454 O43796
Accessions EAW75271 EAW75272 EAW75273 EAW75274 EAW75275 EAW75276 EAW75277 EAW75278 EAW75279 EAW75280 EAW75281 EAW75282 O43526 AF033348 AAB97315 AF074247 AAC25921 AF110020 AAD16988 AK293727 BAG57155 AY358189 AAQ88556 BC000699 AAH00699 BC020384 BC127262 BC146294 AAI46295 BT007043 AAP35692 D82346 BAA11557 Y15065 CAA75348 XM_006723787 XP_006723850 XM_011528807 XP_011527109 XM_011528808 XP_011527110 XM_011528809 XP_011527111 XM_011528810 XP_011527112 XM_011528811 XP_011527113 XM_011528812 XP_011527114 XM_011528813 XP_011527115 XM_011528814 XP_011527116 XM_011528815 XP_011527117 XM_011528816 XP_011527118 NM_004518 NP_004509 NM_172106 NP_742104 NM_172107 NP_742105 NM_172108 NP_742106 NM_172109 NP_742107
Function Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. KCNQ2/KCNQ3 current is blocked by linopirdine and XE991, and activated by the anticonvulsant retigabine. Muscarinic agonist oxotremorine-M strongly suppress KCNQ2/KCNQ3 current in cells in which cloned KCNQ2/KCNQ3 channels were coexpressed with M1 muscarinic receptors.
Subcellular Location Membrane; Multi-pass membrane protein.
Tissue Specificity In adult and fetal brain. Highly expressed in areas containing neuronal cell bodies, low in spinal chord and corpus callosum. Isoform 2 is preferentially expressed in differentiated neurons. Isoform 6 is prominent in fetal brain, undifferentiated neuroblastoma cells and brain tumors. {ECO:0000269|PubMed:10781098}.

Kv7.2 (D9L5S) Rabbit mAb - 14752 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D9L5S
Western blot analysis of extracts from mouse and rat brain membrane using Kv7.2 (D9L5S) Rabbit mAb.

KCNQ2 (C-4) - sc-271852 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
KCNQ2 (C-4): sc-271852. Western blot analysis of KCNQ2 expression in EOC 20 (A) and NIH/3T3 (B) whole cell lysates.

KCNQ2 (E-6) - sc-365114 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
KCNQ2 (E-6): sc-365114. Western blot analysis of KCNQ2 expression in CCD-1064Sk whole cell lysate.

KCNQ2 (C-18) - sc-7792 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

KCNQ2 (F-3) - sc-365115 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
KCNQ2 (F-3): sc-365115. Western blot analysis of KCNQ2 expression in CCD-1064Sk whole cell lysate.

KCNQ2 (H-140) - sc-20817 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
KCNQ2 (H-140): sc-20817. Western blot analysis of KCNQ2 expression in EOC 13.31 (A) and EOC 20 (B) whole cell lysates.

KCNQ2 (N-19) - sc-7793 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
KCNQ2 (N-19): sc-7793. Immunofluorescence staining of methanol-fixed EOC 20 cells showing membrane localization.

Anti-KCNQ2 antibody - ab22897 from Abcam

Prices $398.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-KCNQ2 antibody (ab22897) at 1 µg/mlLane 1 : Rat whole brain lysateLane 2 : Mouse whole brain lysateLysates/proteins at 40 µg per lane.SecondaryAnti-rabbit HRP at 1/20000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-KCNQ2 antibody [S26A-23] - ab84812 from Abcam

Prices $387.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S26A-23
Overlay histogram showing SH-SH5Y cells stained with ab84812 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab84812, 1μg/1x106 cells) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-mouse IgG (H&L) (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in SH-SY5Y cells fixed with 4% paraformaldehyde (10 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-KCNQ2 Antibody (aa179-228) IHC-plus™ - LS-B6609 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-KCNQ2 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6609 concentration 5 ug/ml.

Anti-KCNQ2 Antibody (aa171-220) IHC-plus™ - LS-B6793 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-KCNQ2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6793 concentration 5 ug/ml.

Anti-KCNQ2 Antibody (aa154-203) IHC-plus™ - LS-B981 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-KCNQ2 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B981 concentration 5 ug/ml.

Anti-KCNQ2 Antibody (aa1-59) - LS-C123928 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-KCNQ2 Antibody (N-Terminus) - LS-C144791 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-KCNQ2 Antibody (N-Terminus) - LS-C153516 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-KCNQ2 Antibody (aa1-59, clone S26A-23, Atto 390) - LS-C230686 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S26A-23

Anti-KCNQ2 Antibody (aa1-59, clone S26A-23, Atto 488) - LS-C230689 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S26A-23

Anti-KCNQ2 Antibody (aa1-59, clone S26A-23, Atto 565) - LS-C230690 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S26A-23

Anti-KCNQ2 Antibody (aa1-59, clone S26A-23, Atto 594) - LS-C230691 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S26A-23

Anti-KCNQ2 Antibody (aa1-59, clone S26A-23, Atto 633) - LS-C230692 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S26A-23

Anti-KCNQ2 Antibody (aa1-59, clone S26A-23, Atto 655) - LS-C230693 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S26A-23

Anti-KCNQ2 Antibody (aa1-59, clone S26A-23, Atto 680) - LS-C230694 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S26A-23

Anti-KCNQ2 Antibody (aa1-59, clone S26A-23, Atto 700) - LS-C230695 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S26A-23

Anti-KCNQ2 Antibody (aa1-59, clone S26A-23, AP) - LS-C230696 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S26A-23

Anti-KCNQ2 Antibody (aa1-59, clone S26A-23, Biotin) - LS-C230698 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S26A-23
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