CBFA2T2
| Gene Symbol | CBFA2T2 |
|---|---|
| Entrez Gene | 9139 |
| Alt Symbol | EHT, MTGR1, ZMYND3, p85 |
| Species | Human |
| Gene Type | protein-coding |
| Description | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 |
| Other Description | ETO homolog on chromosome 20|ETO homologous on chromosome 20|MTG8-like protein|MTG8-related protein 1|myeloid translocation gene-related protein 1|myeloid translocation-related protein 1|protein CBFA2T2 |
| Swissprots | O43439 Q5TGE7 Q5TGE4 F8W6D7 Q96L00 Q5TGE5 Q9UJP8 Q9H436 Q96B06 B2RAE6 Q5TGE6 Q9UP24 Q9UJP9 Q8IWF3 |
| Accessions | AAD41221 CCQ43298 EAW76311 EAW76312 EAW76313 O43439 AB209306 BAD92543 AF013970 AAC39841 AF039200 AAC17499 AF052210 AAC64699 AF052211 AAC64700 AF052212 AF068266 AAC19378 AF069747 AAD02825 AK294168 BAG57490 AK307887 AK314159 BAG36843 BC015066 AAH15066 BC016298 AAH16298 BC040344 AAH40344 CB998035 CN347014 CR749462 CAH18294 EU446928 ABZ92457 JF432662 ADZ15879 XM_006723886 XP_006723949 XM_011529101 XP_011527403 XM_011529102 XP_011527404 XM_011529103 XP_011527405 XM_011529104 XP_011527406 XM_011529105 XP_011527407 XM_011529106 XP_011527408 XM_011529107 XP_011527409 NM_001032999 NP_001028171 NM_001039709 NP_001034798 NM_005093 NP_005084 NM_175864 |
| Function | May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region. |
| Subcellular Location | Nucleus {ECO:0000305}. |
| Tissue Specificity | Ubiquitously expressed in fetal and adult tissues. Highly expressed in adult brain, heart, lung, kidney, lymph node, appendix, thymus, testis, uterus, small intestine, prostate and thymus. {ECO:0000269|PubMed:10675041, ECO:0000269|PubMed:9447981, ECO:0000269|PubMed:9787195, ECO:0000269|PubMed:9790752}. |
MTGR1 CRISPR/Cas9 KO Plasmid (h) - sc-408637 from Santa Cruz Biotechnology
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MTGR1 HDR Plasmid (h) - sc-408637-HDR from Santa Cruz Biotechnology
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MTGR1 Double Nickase Plasmid (h) - sc-408637-NIC from Santa Cruz Biotechnology
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MTGR1 Double Nickase Plasmid (h2) - sc-408637-NIC-2 from Santa Cruz Biotechnology
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MTGR1 CRISPR Activation Plasmid (h) - sc-408637-ACT from Santa Cruz Biotechnology
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MTGR1 CRISPR Activation Plasmid (h2) - sc-408637-ACT-2 from Santa Cruz Biotechnology
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MTGR1 Lentiviral Activation Particles (h) - sc-408637-LAC from Santa Cruz Biotechnology
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MTGR1 Lentiviral Activation Particles (h2) - sc-408637-LAC-2 from Santa Cruz Biotechnology
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MTGR1 siRNA (h) - sc-62645 from Santa Cruz Biotechnology
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MTGR1 shRNA Plasmid (h) - sc-62645-SH from Santa Cruz Biotechnology
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MTGR1 shRNA (h) Lentiviral Particles - sc-62645-V from Santa Cruz Biotechnology
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MTGR1 RNAi - H00009139-R03 from Novus Biologicals
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MISSION® esiRNA - EHU146381 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5406 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5406 from Sigma-Aldrich
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CBFA2T2 siRNA (Human) - CRH6045 from Cohesion Biosciences
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MTGR1 RNAi - H00009139-R01 from Novus Biologicals
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MTGR1 RNAi - H00009139-R02 from Novus Biologicals
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CBFA2T2 - MBS829700 from MyBioSource
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shRNA set against Human CBFA2T2 (NM_001032999.2) - SHH255265 from Creative biogene
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shRNA set against Human CBFA2T2(NM_005093.3) - SHG144339 from Creative biogene
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shRNA set against Human CBFA2T2(NM_001032999.2) - SHG144421 from Creative biogene
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shRNA set against Human CBFA2T2(NM_005093.3) - SHG144465 from Creative biogene
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shRNA set against Human CBFA2T2(NM_001039709.1) - SHG144469 from Creative biogene
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Human CBFA2T2 siRNA - orb266547 from Biorbyt
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