| Gene Symbol |
Hdac2
|
| Entrez Gene |
15182
|
| Alt Symbol |
D10Wsu179e, YAF1, Yy1bp, mRPD3
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
histone deacetylase 2
|
| Other Description |
HD2|YY1 transcription factor-binding protein
|
| Swissprots |
B2RRP3 P70288
|
| Accessions |
EDL04897 P70288 AB221663 AK051753 BAC34755 AK135572 BAE22585 AK141649 BAE24786 AK165734 BAE38360 BC138517 AAI38518 U31758 AAC52889 XM_006512555 XP_006512618 NM_008229 NP_032255
|
| Function |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA- replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. I
|
| Subcellular Location |
Nucleus. Cytoplasm {ECO:0000250}.
|
| Top Pathways |
Viral carcinogenesis, Alcoholism, Epstein-Barr virus infection, Cell cycle, Huntington's disease
|