Hdac2

Gene Symbol	Hdac2
Entrez Gene	15182
Alt Symbol	D10Wsu179e, YAF1, Yy1bp, mRPD3
Species	Mouse
Gene Type	protein-coding
Description	histone deacetylase 2
Other Description	HD2|YY1 transcription factor-binding protein
Swissprots	B2RRP3 P70288
Accessions	EDL04897 P70288 AB221663 AK051753 BAC34755 AK135572 BAE22585 AK141649 BAE24786 AK165734 BAE38360 BC138517 AAI38518 U31758 AAC52889 XM_006512555 XP_006512618 NM_008229 NP_032255
Function	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA- replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. I
Subcellular Location	Nucleus. Cytoplasm {ECO:0000250}.
Top Pathways	Viral carcinogenesis, Alcoholism, Epstein-Barr virus infection, Cell cycle, Huntington's disease

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

HDAC2 CRISPR/Cas9 KO Plasmid (m) - sc-420817 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Mouse

HDAC2 HDR Plasmid (m) - sc-420817-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

HDAC2 Double Nickase Plasmid (m) - sc-420817-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

HDAC2 Double Nickase Plasmid (m2) - sc-420817-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

HDAC2 CRISPR Activation Plasmid (m) - sc-420817-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Mouse

HDAC2 CRISPR Activation Plasmid (m2) - sc-420817-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Mouse

HDAC2 Lentiviral Activation Particles (m) - sc-420817-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

HDAC2 Lentiviral Activation Particles (m2) - sc-420817-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

HDAC2 siRNA (m) - sc-29346 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

HDAC2 shRNA Plasmid (m) - sc-29346-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

HDAC2 shRNA (m) Lentiviral Particles - sc-29346-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

MISSION® esiRNA - EMU086861 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN33134 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND33134 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

HDAC2 siRNA (Mouse) - CRM1795 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Mouse

HDAC2 - MBS8227837 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Mouse

HDAC2 CRISPR/Cas9 KO Plasmid (m2) - sc-420817-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Mouse

HDAC2 HDR Plasmid (m2) - sc-420817-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

shRNA set against Mouse HDAC2 (NM_008229.2) - SHH310973 from Creative biogene Category siRNA Species Reactivities Mouse

shRNA set against Mouse Hdac2(NM_008229.2) - SHH116255 from Creative biogene Category siRNA Species Reactivities Mouse

Mouse HDAC2 siRNA - orb281271 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Mouse

HDAC2 shRNA Plasmid (Mouse) - CHM1795 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Mouse

HDAC2 miRNA 3'UTR clone - MiUTR1M-05563 from Creative biogene Species Reactivities Mouse

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