SNAPIN

Gene Symbol SNAPIN
Entrez Gene 23557
Alt Symbol BLOC1S7, BLOS7, SNAPAP
Species Human
Gene Type protein-coding
Description SNAP-associated protein
Other Description BLOC-1 subunit 7|SNAP-25-binding protein|SNARE associated protein snapin|SNARE-associated protein Snapin|biogenesis of lysosomal organelles complex-1, subunit 7|biogenesis of lysosome-related organelles complex 1 subunit 7|synaptosomal-associated protein 25-binding protein
Swissprots Q5SXU8 O95295 D3DV56
Accessions CAI18797 EAW53288 EAW53289 O95295 AA173972 AF086837 AAD11417 AI018675 AK024555 BAB14927 BC000761 AAH00761 BC004494 AAH04494 BE278772 BI117540 BM051828 BT006753 AAP35399 CD671119 NM_012437 NP_036569 NR_052019 NR_052020
Function Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma- membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells. {ECO:000
Subcellular Location Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:18167355, ECO:0000269|PubMed:19168546, ECO:0000269|PubMed:21102408}. Golgi apparatus membrane {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle {ECO:0000250}. Note=May be cytoplasmic and peripheral membrane bound or anchored to the vesicular membrane through an N- terminal signal anchor (By similarity). Colocalizes with NANOS1 and PUM2 in the perinuclear region of germ cells. {ECO:0000250}.
Tissue Specificity Expressed in male germ cells of adult testis (at protein level). {ECO:0000269|PubMed:19168546}.

Snapin CRISPR/Cas9 KO Plasmid (h) - sc-406317 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Snapin HDR Plasmid (h) - sc-406317-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Snapin Double Nickase Plasmid (h) - sc-406317-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Snapin Double Nickase Plasmid (h2) - sc-406317-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Snapin CRISPR Activation Plasmid (h) - sc-406317-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Snapin CRISPR Activation Plasmid (h2) - sc-406317-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Snapin Lentiviral Activation Particles (h) - sc-406317-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Snapin Lentiviral Activation Particles (h2) - sc-406317-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Snapin siRNA (h) - sc-45545 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Snapin shRNA Plasmid (h) - sc-45545-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Snapin shRNA (h) Lentiviral Particles - sc-45545-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN19831 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19831 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR04651 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr04651

SNAPIN siRNA (Human) - CRH8359 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SNAPIN - MBS8220796 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Snapin CRISPR/Cas9 KO Plasmid (h2) - sc-406317-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Snapin HDR Plasmid (h2) - sc-406317-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human SNAPIN (NM_012437.5) - SHH413984 from Creative biogene

Category siRNA
Species Reactivities Human

Human SNAPIN siRNA - orb268861 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SNAPIN shRNA Plasmid (Human) - CHH8359 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SNAPIN miRNA 3'UTR clone - MiUTR3H-08898 from Creative biogene

Species Reactivities Human
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