HAP1

Gene Symbol HAP1
Entrez Gene 9001
Alt Symbol HAP2, HIP5, HLP, hHLP1
Species Human
Gene Type protein-coding
Description huntingtin-associated protein 1
Other Description HAP-1|huntingtin-associated protein 2|neuroan 1
Swissprots Q9H4G3 Q9HA98 A8MQB5 P54257 Q59GK4 Q9NY90 O75358
Accessions CAB82785 CAC09418 EAW60757 EAW60758 EAW60759 EAW60760 EAW60761 P54257 AB209105 BAD92342 AF040723 AAC39861 AK022007 BAB13952 BC156728 AAI56729 CB128405 DA203084 DA231862 U38371 AAC50297 NM_001079870 NP_001073339 NM_001079871 NP_001073340 NM_177977 NP_817084 NM_003949
Function Originally identified as neuronal protein that specifically associates with HTT/huntingtin and the binding is enhanced by an expanded polyglutamine repeat within HTT possibly affecting HAP1 interaction properties. Both HTT and HAP1 are involved in intracellular trafficking and HAP1 is proposed to link HTT to motor proteins and/or transport cargos. Seems to play a role in vesicular transport within neurons and axons such as from early endosomes to late endocytic compartments and to promote neurite outgrowth. The vesicular transport function via association with microtubule-dependent transporters can be attenuated by association with mutant HTT. Involved in the axonal transport of BDNF and its activity-dependent secretion; the function seems to involve HTT, DCTN1 and a complex with SORT1. Involved in APP trafficking and seems to faciltate APP anterograde transport and membrane insertion thereby possibly reducing processing into amyloid beta. Involved in delivery of gamma- aminobutyric ac
Subcellular Location Cytoplasm {ECO:0000269|PubMed:9742138}. Cell projection, axon {ECO:0000269|PubMed:9742138}. Cytoplasm, cytoskeleton {ECO:0000250}. Lysosome {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250}. Mitochondrion {ECO:0000305|PubMed:9742138}. Nucleus {ECO:0000250}. Cytoplasmic vesicle, autophagosome {ECO:0000250}. Note=Localizes to large nonmembrane-bound cytoplasmic bodies found in various types of neurons, called stigmoid bodies (STBs). Localization to neuronal processes and neurite tips is decreased by YWHAZ. In the nucleus localizes to nuclear rods (By similarity). {ECO:0000250}.
Tissue Specificity Predominantly expressed in brain. Selectively expressed in neurons.
Top Pathways Huntington's disease, GABAergic synapse

HAP1 (A-11) - sc-398581 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
HAP1 (A-11): sc-398581. Western blot analysis of HAP1 expression in non-transfected: sc-110760 (A) and human HAP1 transfected: sc-172261 (B) 293 whole cell lysates.

HAP1 (H-300) - sc-30125 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
HAP1 (H-300): sc-30125. Western blot analysis of HAP1 expression in non-transfected: sc-110760 (A) and human HAP1 transfected: sc-172261 (B) 293 whole cell lysates.

HAP1 (N-18) - sc-12556 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
HAP1 (N-18): sc-12556. Western blot analysis of HAP1 expression in non-transfected: sc-117752 (A) and mouse HAP1 transfected: sc-125431 (B) 293T whole cell lysates.

HAP1 (R-19) - sc-8770 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
HAP1 (R-19): sc-8770. Western blot analysis of HAP1 expression in rat brain tissue extract.

Anti-Huntingtin Associated Protein 1 antibody - ab104475 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-Huntingtin Associated Protein 1 antibody - ab190218 from Abcam

Prices $407.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human brain cortex tissue labeling Huntingtin Associated Protein 1 with ab190218 at 3.75 µg/ml.

Anti-Huntingtin Associated Protein 1 antibody - ab58600 from Abcam

Prices $370.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-Huntingtin Associated Protein 1 antibody (ab58600) at 0.1 µg/ml + Human Brain (Hippocampus) lysate (35µg protein in RIPA buffer).

Anti-Huntingtin Associated Protein 1 antibody - ab172242 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-Huntingtin Associated Protein 1 antibody (ab172242) at 1 µg/mlLane 1 : Huntingtin Associated Protein 1-transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG (H+L)-HRP at 1/2500 dilutiondeveloped using the ECL technique

Anti-Huntingtin Associated Protein 1 antibody - ab190227 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin fixed, paraffin-embedded Human adrenal tissue labeling Huntingtin Associated Protein 1 with ab190227 at 10 µg/ml then with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

Anti-HAP1 Antibody (Internal) IHC-plus™ - LS-B1357 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-HAP1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1357 concentration 5 ug/ml.

Anti-HAP1 Antibody - LS-C310570 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HAP1 Antibody (clone 1B6) - LS-C141774 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1B6
Staining of rat hypothalamus.

Anti-HAP1 Antibody (aa639-653) IHC-plus™ - LS-B813 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-HAP1 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B813 concentration 10 ug/ml.

Anti-HAP1 Antibody (aa469-480) IHC-plus™ - LS-B8296 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-HAP1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B8296 dilution 3.75 ug/ml.

HAP1 Antibody - NBP1-76793 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: HAP1 Antibody [NBP1-76793] - Mouse brain tissue lysate with HAP1 antibody at (A) 0.5 and (B) 1 ug/mL.

HAP1 Antibody - NBP1-83294 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

HAP1 Antibody - NB100-55413 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

HAP1 Antibody - H00009001-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Rabbit Anti-HAP1 Polyclonal Antibody - bs-11700R from Bioss

Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded rat brain labeled with Anti-HAP1 Polyclonal Antibody, Unconjugated (bs-11700R) at 1:200 followed by conjugation to the secondary antibody and DAB staining

Rabbit Anti-HAP1 Polyclonal Antibody, Cy3 Conjugated - bs-11700R-Cy3 from Bioss

Host Rabbit
Clonality Polyclonal

Rabbit Anti-HAP1 Polyclonal Antibody, Cy5 Conjugated - bs-11700R-Cy5 from Bioss

Host Rabbit
Clonality Polyclonal
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