HAP1

Gene Symbol	HAP1
Entrez Gene	9001
Alt Symbol	HAP2, HIP5, HLP, hHLP1
Species	Human
Gene Type	protein-coding
Description	huntingtin-associated protein 1
Other Description	HAP-1|huntingtin-associated protein 2|neuroan 1
Swissprots	Q9H4G3 Q9HA98 A8MQB5 P54257 Q59GK4 Q9NY90 O75358
Accessions	CAB82785 CAC09418 EAW60757 EAW60758 EAW60759 EAW60760 EAW60761 P54257 AB209105 BAD92342 AF040723 AAC39861 AK022007 BAB13952 BC156728 AAI56729 CB128405 DA203084 DA231862 U38371 AAC50297 NM_001079870 NP_001073339 NM_001079871 NP_001073340 NM_177977 NP_817084 NM_003949
Function	Originally identified as neuronal protein that specifically associates with HTT/huntingtin and the binding is enhanced by an expanded polyglutamine repeat within HTT possibly affecting HAP1 interaction properties. Both HTT and HAP1 are involved in intracellular trafficking and HAP1 is proposed to link HTT to motor proteins and/or transport cargos. Seems to play a role in vesicular transport within neurons and axons such as from early endosomes to late endocytic compartments and to promote neurite outgrowth. The vesicular transport function via association with microtubule-dependent transporters can be attenuated by association with mutant HTT. Involved in the axonal transport of BDNF and its activity-dependent secretion; the function seems to involve HTT, DCTN1 and a complex with SORT1. Involved in APP trafficking and seems to faciltate APP anterograde transport and membrane insertion thereby possibly reducing processing into amyloid beta. Involved in delivery of gamma- aminobutyric ac
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:9742138}. Cell projection, axon {ECO:0000269|PubMed:9742138}. Cytoplasm, cytoskeleton {ECO:0000250}. Lysosome {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250}. Mitochondrion {ECO:0000305|PubMed:9742138}. Nucleus {ECO:0000250}. Cytoplasmic vesicle, autophagosome {ECO:0000250}. Note=Localizes to large nonmembrane-bound cytoplasmic bodies found in various types of neurons, called stigmoid bodies (STBs). Localization to neuronal processes and neurite tips is decreased by YWHAZ. In the nucleus localizes to nuclear rods (By similarity). {ECO:0000250}.
Tissue Specificity	Predominantly expressed in brain. Selectively expressed in neurons.
Top Pathways	Huntington's disease, GABAergic synapse

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

HAP1 Antibody Blocking Peptide - LS-E26219 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HAP1 Antibody Blocking Peptide - LS-E30344 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

HAP1 Antibody Blocking Peptide - LS-E26344 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HAP1 Blocking Peptide - NBP1-76793PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

HAP1 blocking peptide - GTX89202-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

Huntingtin Associated Protein 1 Peptide - AC21-1050-P from Abcore Category Protein Prices $160.00 Sizes 100 µg

HAP1 Control Peptide - AP30391CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

HAP1 Peptide - 45-721P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

HAP1 Peptide - 4205P from ProSci Category Peptide Species Human

HAP1 fusion protein - ag17705 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

HAP1 fusion protein - ag16248 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human HAP1 - HAP1-499H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Recombinant Huntingtin Associated Protein 1 (HAP1) - RPH923Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Huntingtin Associated Protein 1 (HAP1) - RPH923Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Human Huntingtin-associated protein 1(HAP1) - CSB-YP010129HU CSB-EP010129HU CSB-BP010129HU CSB-MP010129HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Huntingtin Associated Protein 1 (HAP1) - RPH923Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

HAP1, Peptide - MBS426748 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human

HAP1 Recombinant Protein Antigen - NBP1-83294PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Huntingtin-Associated-Protein-1-HAP1-antibody-Blocking-peptide - BP6118a from Abgent, a WuXi AppTec company Category Protein Prices $80.00 Sizes 100 µg

HAP1 Peptide, Human - M34GP06832H from Creative Peptides Category Peptide Source Synthetic. Species Human

HAP1 Recombinant Protein (OPCD03796) - OPCD03796 from Aviva Systems Biology Category Protein Source E.coli Species Human

Huntingtin-associated protein 1 (HAP1), Recombinant Protein - MBS949696 from MyBioSource Category Protein Prices $1,475.00, $1,475.00, $1,700.00, $1,700.00, $2,510.00, $2,510.00, $2,950.00, $2,950.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

HAP1 Recombinant Protein Antigen - NBP2-57650PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Hap1 Immunizing peptide - orb50318 from Biorbyt Category Peptide

Recombinant Human HAP1 protein, His & GST-tagged - HAP1-1598H from Creative Biomart Category Protein Source E. coli Species Human

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