HAP1

Gene Symbol HAP1
Entrez Gene 9001
Alt Symbol HAP2, HIP5, HLP, hHLP1
Species Human
Gene Type protein-coding
Description huntingtin-associated protein 1
Other Description HAP-1|huntingtin-associated protein 2|neuroan 1
Swissprots Q9H4G3 Q9HA98 A8MQB5 P54257 Q59GK4 Q9NY90 O75358
Accessions CAB82785 CAC09418 EAW60757 EAW60758 EAW60759 EAW60760 EAW60761 P54257 AB209105 BAD92342 AF040723 AAC39861 AK022007 BAB13952 BC156728 AAI56729 CB128405 DA203084 DA231862 U38371 AAC50297 NM_001079870 NP_001073339 NM_001079871 NP_001073340 NM_177977 NP_817084 NM_003949
Function Originally identified as neuronal protein that specifically associates with HTT/huntingtin and the binding is enhanced by an expanded polyglutamine repeat within HTT possibly affecting HAP1 interaction properties. Both HTT and HAP1 are involved in intracellular trafficking and HAP1 is proposed to link HTT to motor proteins and/or transport cargos. Seems to play a role in vesicular transport within neurons and axons such as from early endosomes to late endocytic compartments and to promote neurite outgrowth. The vesicular transport function via association with microtubule-dependent transporters can be attenuated by association with mutant HTT. Involved in the axonal transport of BDNF and its activity-dependent secretion; the function seems to involve HTT, DCTN1 and a complex with SORT1. Involved in APP trafficking and seems to faciltate APP anterograde transport and membrane insertion thereby possibly reducing processing into amyloid beta. Involved in delivery of gamma- aminobutyric ac
Subcellular Location Cytoplasm {ECO:0000269|PubMed:9742138}. Cell projection, axon {ECO:0000269|PubMed:9742138}. Cytoplasm, cytoskeleton {ECO:0000250}. Lysosome {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250}. Mitochondrion {ECO:0000305|PubMed:9742138}. Nucleus {ECO:0000250}. Cytoplasmic vesicle, autophagosome {ECO:0000250}. Note=Localizes to large nonmembrane-bound cytoplasmic bodies found in various types of neurons, called stigmoid bodies (STBs). Localization to neuronal processes and neurite tips is decreased by YWHAZ. In the nucleus localizes to nuclear rods (By similarity). {ECO:0000250}.
Tissue Specificity Predominantly expressed in brain. Selectively expressed in neurons.
Top Pathways Huntington's disease, GABAergic synapse

Human HAP1 ELISA Kit (Sandwich ELISA) - LS-F9017 from LifeSpan Bioscience

Category ELISA Kit
Prices $720.00
Sizes 1 plate
Sensitivity 0.113 ng/ml
Range 0.313-20 ng/ml

Human HAP1 ELISA Kit - abx151771 from Abbexa

Category ELISA Kit
Sensitivity 0.113 ng/ml
Range 0.313 ng/ml - 20 ng/ml

huntingtin-associated protein 1, ELISA Kit - MBS922159 from MyBioSource

Category ELISA Kit
Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00
Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 15.6 pg/ml.
Range 62.5 pg/ml -4000 pg/ml.

ELISA Kit for Huntingtin Associated Protein 1 (HAP1) - SEH923Hu from Uscn Life Science Inc.

Category ELISA Kit
Sensitivity The minimum detectable dose of this kit is typically less than 0.113ng/mL.
Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Human Huntingtin-associated protein 1(HAP1) ELISA kit - CSB-EL010129HU from Cusabio

Category ELISA Kit
Sensitivity 15.6 pg/ml
Range 62.5 pg/ml-4000 pg/ml

Huntingtin Associated Protein 1 (HAP1), Human, ELISA Kit - DL-HAP1-Hu from ARP American Research Products

Category ELISA Kit
Prices $655.00
Sizes 96 t
Range 0.312-20 ng/mL

Human HAP1 ELISA Kit - E019042 from Biobool

Category ELISA Kit
Sensitivity Typically less than 0.113ng/mL.

HAP1 ELISA Kit (Human) (OKCD01042) - OKCD01042 from Aviva Systems Biology

Category ELISA Kit
Prices $545.00
Sizes 96 wells
Sensitivity < 0.113 ng/mL
Range 0.312-20 ng/mL

anti-Hap1 antibody - ARG64197 from Arigo Biolaboratories

Category ELISA Kit

anti-HAP1 antibody - ARG64076 from Arigo Biolaboratories

Category ELISA Kit

Huntingtin Associated Protein 1 (HAP1), ELISA Kit - MBS455847 from MyBioSource

Category ELISA Kit
Prices $415.00, $550.00, $2,425.00, $4,710.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity <0.113ng/mL
Range 0.312-20ng/mL

Human HAP1 ELISA Kit - orb406425 from Biorbyt

Category ELISA Kit
Sensitivity 15.6 pg/ml
Range 62.5 pg/ml-4000 pg/ml
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