Gene Symbol | NCR1 |
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Entrez Gene | 9437 |
Alt Symbol | CD335, LY94, NK-p46, NKP46 |
Species | Human |
Gene Type | protein-coding |
Description | natural cytotoxicity triggering receptor 1 |
Other Description | NK cell-activating receptor|lymphocyte antigen 94 homolog (activating NK-receptor; NK-p46)|natural killer cell p46-related protein |
Swissprots | O76017 O76018 O76016 B0V3L5 B0V3L4 O76036 B0V3L2 B8JL03 B0V3L3 |
Accessions | EAW72308 EAW72309 EAW72310 EAW72311 EAW72312 O76036 AJ001383 CAA04714 AJ006121 CAA06872 AJ006122 CAA06873 AJ006123 CAA06874 AY346373 AAQ54328 BC064806 AAH64806 HQ448088 ADQ32569 XM_011527528 XP_011525830 XM_011527529 XP_011525831 XM_011527530 XP_011525832 XM_011547125 XP_011545427 XM_011547126 XP_011545428 XM_011547127 XP_011545429 XM_011547535 XP_011545837 XM_011547536 XP_011545838 XM_011547537 XP_011545839 XM_011547798 XP_011546100 XM_011547799 XP_011546101 XM_011547800 XP_011546102 XM_011547993 XP_011546295 XM_011547994 XP_011546296 XM_011547995 XP_011546297 XM_011548172 XP_011546474 XM_011548173 XP_011546475 XM_011548174 XP_011546476 XM_011548364 XP_011546666 XM_011548365 XP_011546667 XM_011548366 XP_011546668 XM_011548571 XP_011546873 XM_011548572 XP_011546874 XM_011548573 XP_011546875 XM_011548629 XP_011546931 XM_011548630 XP_011546932 XM_011548631 XP_011546933 XM_011548718 XP_011547020 XM_011548719 XP_011547021 XM_011548720 XP_011547022 NM_001145457 NP_001138929 NM_001145458 NP_001138930 NM_001242356 NP_001229285 NM_001242357 NP_001229286 NM_004829 NP_004820 |
Function | Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. {ECO:0000269|PubMed:9730896}. |
Subcellular Location | Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. |
Tissue Specificity | Selectively expressed by both resting and activated NK cells. {ECO:0000269|PubMed:9730896}. |
Top Pathways | Natural killer cell mediated cytotoxicity |
NKp46 CRISPR/Cas9 KO Plasmid (h) - sc-417222 from Santa Cruz Biotechnology
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NKp46 HDR Plasmid (h) - sc-417222-HDR from Santa Cruz Biotechnology
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NKp46 Double Nickase Plasmid (h) - sc-417222-NIC from Santa Cruz Biotechnology
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NKp46 Double Nickase Plasmid (h2) - sc-417222-NIC-2 from Santa Cruz Biotechnology
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NKp46 CRISPR Activation Plasmid (h) - sc-417222-ACT from Santa Cruz Biotechnology
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NKp46 CRISPR Activation Plasmid (h2) - sc-417222-ACT-2 from Santa Cruz Biotechnology
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NKp46 Lentiviral Activation Particles (h) - sc-417222-LAC from Santa Cruz Biotechnology
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NKp46 Lentiviral Activation Particles (h2) - sc-417222-LAC-2 from Santa Cruz Biotechnology
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NKp46 siRNA (h) - sc-42951 from Santa Cruz Biotechnology
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NKp46 shRNA Plasmid (h) - sc-42951-SH from Santa Cruz Biotechnology
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NKp46 shRNA (h) Lentiviral Particles - sc-42951-V from Santa Cruz Biotechnology
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NKp46/NCR1 RNAi - H00009437-R02 from Novus Biologicals
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MISSION® esiRNA - EHU071021 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15036 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15036 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00332 from Sigma-Aldrich
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NCR1 siRNA (Human) - CRH6257 from Cohesion Biosciences
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shRNA set against Human NCR1 (NM_004829.5) - SHH350180 from Creative biogene
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Human NKp46 siRNA - orb266759 from Biorbyt
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NCR1 shRNA Plasmid (Human) - CHH6257 from Cohesion Biosciences
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