Gene Symbol | Plcg1 |
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Entrez Gene | 18803 |
Alt Symbol | AI894140, Cded, Plc-1, Plc-gamma1, Plcg-1 |
Species | Mouse |
Gene Type | protein-coding |
Description | phospholipase C, gamma 1 |
Other Description | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1|1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1|1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1|PLC-gamma-1|cell differentiation and embryonic development|phosphoinositide phospholipase C-gamma-1|phospholipase C-gamma-1 |
Swissprots | Q62077 Q6P1G1 |
Accessions | AAX90611 CBF62965 CBF74731 CBU87841 CBU96788 EDL06290 EDL06291 EDL06292 Q62077 AF027185 AAD09344 AK134041 BAE21990 AK160731 BAE35976 AK162809 AK169695 BAE41310 AK169777 BAE41359 AK185701 BC057161 BC065091 AAH65091 X95346 CAA64639 NM_021280 NP_067255 |
Function | Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand- mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration. {ECO:0000269|PubMed:15308098}. |
Subcellular Location | Cell projection, lamellipodium {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Note=Rapidly redistributed to ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment. {ECO:0000250}. |
Top Pathways | Epstein-Barr virus infection, Proteoglycans in cancer, Rap1 signaling pathway, Choline metabolism in cancer, VEGF signaling pathway |
PLCG1 antibody (Tyr783) - 70R-31041 from Fitzgerald
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PLCG1 antibody (Tyr771) - 70R-31039 from Fitzgerald
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PLCG1 antibody - 70R-31042 from Fitzgerald
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PLCG1 antibody - 70R-31040 from Fitzgerald
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PLCG1, Polyclonal Antibody - MBS2529592 from MyBioSource
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PLCG1, Polyclonal Antibody - MBS2529626 from MyBioSource
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PLCG1, Polyclonal Antibody - MBS2523233 from MyBioSource
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PLCg1 - MBS6003055 from MyBioSource
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PLC gamma 1 antibody - 70R-50217 from Fitzgerald
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PLC gamma 1 antibody - 70R-50215 from Fitzgerald
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PLC gamma 1 antibody - 70R-50216 from Fitzgerald
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PLCG1 antibody - 70R-51609 from Fitzgerald
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anti-PLC gamma1 phospho (Tyr771) antibody - ARG51818 from Arigo Biolaboratories |
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anti-PLC gamma1 phospho (Tyr783) antibody - ARG51605 from Arigo Biolaboratories |