| Gene Symbol |
Plcg1
|
| Entrez Gene |
18803
|
| Alt Symbol |
AI894140, Cded, Plc-1, Plc-gamma1, Plcg-1
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
phospholipase C, gamma 1
|
| Other Description |
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1|1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1|1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1|PLC-gamma-1|cell differentiation and embryonic development|phosphoinositide phospholipase C-gamma-1|phospholipase C-gamma-1
|
| Swissprots |
Q62077 Q6P1G1
|
| Accessions |
AAX90611 CBF62965 CBF74731 CBU87841 CBU96788 EDL06290 EDL06291 EDL06292 Q62077 AF027185 AAD09344 AK134041 BAE21990 AK160731 BAE35976 AK162809 AK169695 BAE41310 AK169777 BAE41359 AK185701 BC057161 BC065091 AAH65091 X95346 CAA64639 NM_021280 NP_067255
|
| Function |
Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand- mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration. {ECO:0000269|PubMed:15308098}.
|
| Subcellular Location |
Cell projection, lamellipodium {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Note=Rapidly redistributed to ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment. {ECO:0000250}.
|
| Top Pathways |
Epstein-Barr virus infection, Proteoglycans in cancer, Rap1 signaling pathway, Choline metabolism in cancer, VEGF signaling pathway
|