| Gene Symbol |
SLC26A7
|
| Entrez Gene |
115111
|
| Alt Symbol |
SUT2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 26 (anion exchanger), member 7
|
| Other Description |
anion exchange transporter|solute carrier family 26, member 7|sulfate anion transporter
|
| Swissprots |
Q8TE53 Q96RN2 Q24JS8 Q8TE54
|
| Accessions |
CAF06391 EAW91679 EAW91680 Q8TE54 AF331521 AAK95665 AI758950 AJ413228 CAC88370 AJ413229 CAC88371 AJ413230 CAC88372 AK122933 AW235609 BC113866 AAI13867 BC114474 AAI14475 NM_001282356 NP_001269285 NM_001282357 NP_001269286 NM_052832 NP_439897 NM_134266 NP_599028
|
| Function |
Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment-specific anion exchanger. Plays a major role in gastric acid secretion. {ECO:0000250|UniProtKB:Q8R2Z3, ECO:0000269|PubMed:11834742, ECO:0000269|PubMed:12736153}.
|
| Subcellular Location |
Recycling endosome membrane {ECO:0000269|PubMed:16524946}; Multi-pass membrane protein {ECO:0000269|PubMed:16524946}. Note=Expressed in the cytoplasm in recycling endosomes of medullary collecting duct cells and in acid-secreting gastric parietal cells. Targeted to the basolateral membrane in hypertonicity and potassium depletion. {ECO:0000269|PubMed:16524946}.
|
| Tissue Specificity |
Expressed in tonsillar high endothelial venule endothelial cells (HEVEC), placenta and in testis, expressed in a subgroup of basal cells in the epididymal ducts. {ECO:0000269|PubMed:11829495, ECO:0000269|PubMed:11834742, ECO:0000269|PubMed:15956810, ECO:0000269|PubMed:17504921}.
|
| Top Pathways |
Gastric acid secretion
|