| Gene Symbol | SLC26A7 |
|---|---|
| Entrez Gene | 115111 |
| Alt Symbol | SUT2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | solute carrier family 26 (anion exchanger), member 7 |
| Other Description | anion exchange transporter|solute carrier family 26, member 7|sulfate anion transporter |
| Swissprots | Q8TE53 Q96RN2 Q24JS8 Q8TE54 |
| Accessions | CAF06391 EAW91679 EAW91680 Q8TE54 AF331521 AAK95665 AI758950 AJ413228 CAC88370 AJ413229 CAC88371 AJ413230 CAC88372 AK122933 AW235609 BC113866 AAI13867 BC114474 AAI14475 NM_001282356 NP_001269285 NM_001282357 NP_001269286 NM_052832 NP_439897 NM_134266 NP_599028 |
| Function | Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment-specific anion exchanger. Plays a major role in gastric acid secretion. {ECO:0000250|UniProtKB:Q8R2Z3, ECO:0000269|PubMed:11834742, ECO:0000269|PubMed:12736153}. |
| Subcellular Location | Recycling endosome membrane {ECO:0000269|PubMed:16524946}; Multi-pass membrane protein {ECO:0000269|PubMed:16524946}. Note=Expressed in the cytoplasm in recycling endosomes of medullary collecting duct cells and in acid-secreting gastric parietal cells. Targeted to the basolateral membrane in hypertonicity and potassium depletion. {ECO:0000269|PubMed:16524946}. |
| Tissue Specificity | Expressed in tonsillar high endothelial venule endothelial cells (HEVEC), placenta and in testis, expressed in a subgroup of basal cells in the epididymal ducts. {ECO:0000269|PubMed:11829495, ECO:0000269|PubMed:11834742, ECO:0000269|PubMed:15956810, ECO:0000269|PubMed:17504921}. |
| Top Pathways | Gastric acid secretion |
SLC26A7 CRISPR/Cas9 KO Plasmid (h) - sc-404627 from Santa Cruz Biotechnology
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SLC26A7 HDR Plasmid (h) - sc-404627-HDR from Santa Cruz Biotechnology
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SLC26A7 Double Nickase Plasmid (h) - sc-404627-NIC from Santa Cruz Biotechnology
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SLC26A7 Double Nickase Plasmid (h2) - sc-404627-NIC-2 from Santa Cruz Biotechnology
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SLC26A7 CRISPR Activation Plasmid (h) - sc-404627-ACT from Santa Cruz Biotechnology
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SLC26A7 CRISPR Activation Plasmid (h2) - sc-404627-ACT-2 from Santa Cruz Biotechnology
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SLC26A7 Lentiviral Activation Particles (h) - sc-404627-LAC from Santa Cruz Biotechnology
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SLC26A7 Lentiviral Activation Particles (h2) - sc-404627-LAC-2 from Santa Cruz Biotechnology
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SLC26A7 siRNA (h) - sc-72023 from Santa Cruz Biotechnology
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SLC26A7 shRNA Plasmid (h) - sc-72023-SH from Santa Cruz Biotechnology
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SLC26A7 shRNA (h) Lentiviral Particles - sc-72023-V from Santa Cruz Biotechnology
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SLC26A7 siRNA (h) - sc-77858 from Santa Cruz Biotechnology
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SLC26A7 shRNA Plasmid (h) - sc-77858-SH from Santa Cruz Biotechnology
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SLC26A7 shRNA (h) Lentiviral Particles - sc-77858-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU086011 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19528 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19528 from Sigma-Aldrich
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SLC26A7 siRNA (Human) - CRJ4430 from Cohesion Biosciences
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SLC26A7 - MBS8225248 from MyBioSource
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shRNA set against Human SLC26A7 (NM_052832.2) - SHH410004 from Creative biogene
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shRNA set against Human SLC26A7(NM_134266.1) - SHL004644 from Creative biogene
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shRNA set against Human SLC26A7(NM_052832.2) - SHL004662 from Creative biogene
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SLC26A7 shRNA Plasmid (Human) - CHJ4430 from Cohesion Biosciences
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SLC26A7 miRNA 3'UTR clone - MiUTR1H-09501 from Creative biogene
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SLC26A7 miRNA 3'UTR clone - MiUTR1H-09502 from Creative biogene
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