RPS6KA3
| Gene Symbol | RPS6KA3 |
|---|---|
| Entrez Gene | 6197 |
| Alt Symbol | CLS, HU-3, ISPK-1, MAPKAPK1B, MRX19, RSK, RSK2, S6K-alpha3, p90-RSK2, pp90RSK2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ribosomal protein S6 kinase, 90kDa, polypeptide 3 |
| Other Description | MAP kinase-activated protein kinase 1b|MAPK-activated protein kinase 1b|MAPKAP kinase 1b|MAPKAPK-1b|RSK-2|S6K-alpha-3|insulin-stimulated protein kinase 1|p90-RSK 3|ribosomal S6 kinase 2|ribosomal protein S6 kinase alpha-3 |
| Swissprots | Q7Z3Z7 P51812 Q5JPK8 B2R9V4 Q59H26 Q4VAP3 |
| Accessions | AAL87803 BAC80810 BAC80811 BAC80812 BAC80813 BAC80814 BAC80815 BAC80816 BAC80817 BAC80818 BAC80819 BAC80820 BAC80821 BAC80822 BAC80823 BAC80824 BAC80825 BAC80826 BAC80827 BAC80828 BAC80829 BAC80840 BAC80841 BAC80842 BAC80843 BAC80844 BAC80845 BAC80846 BAC80847 BAC80848 BAC80849 BAC80850 BAC80851 BAC80852 BAC80853 BAC80854 BAC80855 BAC80856 BAC80857 BAC80858 BAC80859 BAC80870 BAC80871 BAC80872 BAC80873 BAC80874 BAC80875 BAC80876 BAC80877 BAC80878 BAC80879 BAC80880 BAC80881 BAC80882 BAC80883 BAC80884 BAC80885 BAC80886 BAC80887 BAC80888 BAC80889 P51812 AA317826 AA858312 AB102662 BAC81131 AB208933 BAD92170 AK022869 AK294373 BAG57633 AK296775 BAG59354 AK313932 BAG36651 AK316482 BAH14853 AV684171 BC015451 BC096301 AAH96301 BC096302 AAH96302 BC096303 AAH96303 BQ427696 BU618685 CA843287 CA843526 CK905714 L07599 AAC82495 U08316 AAA81952 W00439 XM_005274573 XP_005274630 XM_005274577 XP_005274634 XM_006724507 XP_006724570 XM_011545555 XP_011543857 XM_011545556 XP_011543858 XM_011545557 XP_011543859 XM_011545558 XP_011543860 XM_011545559 XP_011543861 XM_011545560 XP_011543862 XM_011545561 XP_011543863 XM_011545562 XP_011543864 XM_011545563 XP_011543865 NM_004586 NP_004577 |
| Function | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at 'Ser-10', which results in the subsequent transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity. Phosphorylates RPS6 in response to serum or EGF via an mTOR- indepe |
| Subcellular Location | Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. |
| Tissue Specificity | Expressed in many tissues, highest levels in skeletal muscle. |
| Top Pathways | Long-term potentiation, Progesterone-mediated oocyte maturation, MAPK signaling pathway, Neurotrophin signaling pathway, Oocyte meiosis |
Rsk-2 CRISPR/Cas9 KO Plasmid (h) - sc-401003 from Santa Cruz Biotechnology
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Rsk-2 HDR Plasmid (h) - sc-401003-HDR from Santa Cruz Biotechnology
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Rsk-2 Double Nickase Plasmid (h) - sc-401003-NIC from Santa Cruz Biotechnology
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Rsk-2 Double Nickase Plasmid (h2) - sc-401003-NIC-2 from Santa Cruz Biotechnology
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Rsk-2 CRISPR Activation Plasmid (h) - sc-401003-ACT from Santa Cruz Biotechnology
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Rsk-2 CRISPR Activation Plasmid (h2) - sc-401003-ACT-2 from Santa Cruz Biotechnology
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Rsk-2 Lentiviral Activation Particles (h) - sc-401003-LAC from Santa Cruz Biotechnology
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Rsk-2 Lentiviral Activation Particles (h2) - sc-401003-LAC-2 from Santa Cruz Biotechnology
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Rsk-2 siRNA (h) - sc-36441 from Santa Cruz Biotechnology
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Rsk-2 shRNA Plasmid (h) - sc-36441-SH from Santa Cruz Biotechnology
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Rsk-2 shRNA (h) Lentiviral Particles - sc-36441-V from Santa Cruz Biotechnology
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RSK2 RNAi - H00006197-R02 from Novus Biologicals
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MISSION® esiRNA - EHU025521 from Sigma-Aldrich
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MISSION® siRNA - SIHK2012 from Sigma-Aldrich
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MISSION® siRNA - SIHK2011 from Sigma-Aldrich
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MISSION® siRNA - SIHK2010 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2232 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2232 from Sigma-Aldrich
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RPS6KA3 siRNA (Human) - CRH4172 from Cohesion Biosciences
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RPS6KA3 - MBS8226089 from MyBioSource
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shRNA set against Human RPS6KA3 (NM_004586.2) - SHH399564 from Creative biogene
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shRNA set against Human RPS6KA3(NM_004586.2) - SHR197778 from Creative biogene
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RPS6KA3 shRNA Plasmid (Human) - CHH4172 from Cohesion Biosciences
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RPS6KA3 miRNA 3'UTR clone - MiUTR1H-09028 from Creative biogene
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