RPS6KA3

Gene Symbol RPS6KA3
Entrez Gene 6197
Alt Symbol CLS, HU-3, ISPK-1, MAPKAPK1B, MRX19, RSK, RSK2, S6K-alpha3, p90-RSK2, pp90RSK2
Species Human
Gene Type protein-coding
Description ribosomal protein S6 kinase, 90kDa, polypeptide 3
Other Description MAP kinase-activated protein kinase 1b|MAPK-activated protein kinase 1b|MAPKAP kinase 1b|MAPKAPK-1b|RSK-2|S6K-alpha-3|insulin-stimulated protein kinase 1|p90-RSK 3|ribosomal S6 kinase 2|ribosomal protein S6 kinase alpha-3
Swissprots Q7Z3Z7 P51812 Q5JPK8 B2R9V4 Q59H26 Q4VAP3
Accessions AAL87803 BAC80810 BAC80811 BAC80812 BAC80813 BAC80814 BAC80815 BAC80816 BAC80817 BAC80818 BAC80819 BAC80820 BAC80821 BAC80822 BAC80823 BAC80824 BAC80825 BAC80826 BAC80827 BAC80828 BAC80829 BAC80840 BAC80841 BAC80842 BAC80843 BAC80844 BAC80845 BAC80846 BAC80847 BAC80848 BAC80849 BAC80850 BAC80851 BAC80852 BAC80853 BAC80854 BAC80855 BAC80856 BAC80857 BAC80858 BAC80859 BAC80870 BAC80871 BAC80872 BAC80873 BAC80874 BAC80875 BAC80876 BAC80877 BAC80878 BAC80879 BAC80880 BAC80881 BAC80882 BAC80883 BAC80884 BAC80885 BAC80886 BAC80887 BAC80888 BAC80889 P51812 AA317826 AA858312 AB102662 BAC81131 AB208933 BAD92170 AK022869 AK294373 BAG57633 AK296775 BAG59354 AK313932 BAG36651 AK316482 BAH14853 AV684171 BC015451 BC096301 AAH96301 BC096302 AAH96302 BC096303 AAH96303 BQ427696 BU618685 CA843287 CA843526 CK905714 L07599 AAC82495 U08316 AAA81952 W00439 XM_005274573 XP_005274630 XM_005274577 XP_005274634 XM_006724507 XP_006724570 XM_011545555 XP_011543857 XM_011545556 XP_011543858 XM_011545557 XP_011543859 XM_011545558 XP_011543860 XM_011545559 XP_011543861 XM_011545560 XP_011543862 XM_011545561 XP_011543863 XM_011545562 XP_011543864 XM_011545563 XP_011543865 NM_004586 NP_004577
Function Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at 'Ser-10', which results in the subsequent transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity. Phosphorylates RPS6 in response to serum or EGF via an mTOR- indepe
Subcellular Location Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
Tissue Specificity Expressed in many tissues, highest levels in skeletal muscle.
Top Pathways Long-term potentiation, Progesterone-mediated oocyte maturation, MAPK signaling pathway, Neurotrophin signaling pathway, Oocyte meiosis

RSK2 (D21B2) XP ® Rabbit mAb - 5528 from Cell Signaling Technology

Prices $109.00, $277.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D21B2
Western blot analysis of extracts from various cell lines using RSK2 (D21B2) XP ® Rabbit mAb.

RSK2 Antibody - 9340 from Cell Signaling Technology

Prices $239.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of purified RSK1, RSK2 and RSK3 proteins using RSK1 Antibody #9333 (upper), RSK2 Antibody (middle) or RSK3 Antibody #9343 (lower).

Phospho-RSK2 (Tyr529) Antibody - 9324 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

Rsk (H-60) - sc-28773 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Rsk (H-60): sc-28773. Western blot analysis of Rsk expression in A-431 whole cell lysate.

Rsk-2 (C-19) - sc-1430 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Rsk-2 (C-19): sc-1430. Western blot analysis of Rsk-2 expression in A-431 (A) and NIH/3T3 (B) whole cell lysates.

Rsk-2 (E-1) - sc-9986 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Rsk-2 (E-1): sc-9986. Western blot analysis of Rsk-2 expression in HeLa (A) and MCF7 (B) whole cell lysates.

Rsk-2 (L-13) - sc-30700 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

p-Rsk (Ser 227) - sc-12445 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p-Rsk (Ser 227)-R: sc-12445-R. Western blot analysis of Rsk phosphorylation in untreated (A), PMA treated (B) and PMA and lambda protein phosphatase treated (C) HeLa whole cell lysates.

p-Rsk-2 (C-6) - sc-377501 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Western blot analysis of Rsk-2 phosphorylation in untreated (A,D), PMA treated (B,E) and PMA and lambda protein phosphatase (sc-200312A) treated (C,F) HeLa whole cell lysates. Antibodies tested include p-Rsk-2 (C-6): sc-377501 (A,B,C) and Rsk-2 (C-19): sc-1430 (D,E,F).

p-Rsk-2 (F-7) - sc-374664 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Western blot analysis of Rsk-2 phosphorylation in untreated (A,D), PMA treated (B,E) and PMA and lambda protein phosphatase treated (C,F) HeLa whole cell lysates. Antibodies tested include p-Rsk-2 (F-7): sc-374664 (A,B,C) and Rsk-2 (C-19): sc-1430 (D,E,F).

p-Rsk-2 (Thr 577) - sc-16407 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p-Rsk-2 (Thr 577): sc-16407. Immunoperoxidase staining of formalin fixed, paraffin-embedded human skeletal muscle tissue showing cytoplasmic, membrane and nuclear staining of myocytes.

Anti-Rsk 2 / MAPKAP Kinase 1b (phospho S227) antibody [EPR2847Y] - ab75820 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2847Y
All lanes : Anti-Rsk 2 / MAPKAP Kinase 1b (phospho S227) antibody [EPR2847Y] (ab75820) at 1/2000 dilutionLane 1 : HeLa cell lysates, untreatedLane 2 : HeLa cell lysates, treated with calyculin ALysates/proteins at 10 µg per lane.Secondarygoat anti-rabbit HRP at 1/2000 dilution

Anti-Rsk 2 / MAPKAP Kinase 1b antibody - ab167581 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-Rsk 2 / MAPKAP Kinase 1b antibody (ab167581) at 1/500 dilutionLane 1 : Rsk 2 / MAPKAP Kinase 1b transfected 293T cell lysateLane 2 : Non transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate secondary antibody at 1/2500 dilution

Anti-Rsk 2 / MAPKAP Kinase 1b antibody - ab18907 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Rsk 2 / MAPKAP Kinase 1b antibody [4E10] - ab119931 from Abcam

Host Mouse
Clonality Monoclonal
Clone 4E10
Anti-Rsk 2 / MAPKAP Kinase 1b antibody [4E10] (ab119931) at 1/500 dilution + Recombinant Rsk 2 / MAPKAP Kinase 1b protein

Anti-Rsk 2 / MAPKAP Kinase 1b antibody [Y82] - ab32062 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone Y82
Overlay histogram showing MCF7 cells stained with ab32062 (red line). The cells were fixed with 4% paraformaldehyde (10 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab32062, 1/1000 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-rabbit IgG (H&L) (ab150077) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (0.1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in MCF7 cells fixed with 80% methanol (5 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-Rsk 2 / MAPKAP Kinase 1b antibody [Y83] - ab32133 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone Y83
Anti-Rsk 2 / MAPKAP Kinase 1b antibody [Y83] (ab32133) at 1/5000 dilution + Hela cell lysate

Anti-RPS6KA3 / RSK2 Antibody - LS-C48507 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-RPS6KA3 / RSK2 Antibody (Glu719) - LS-C75547 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-RPS6KA3 / RSK2 Antibody (C-Terminus) - LS-C83023 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-RPS6KA3 / RSK2 Antibody (phospho-Ser369) - LS-C96796 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Dot blot of anti-RPS6KA3-pS369 Phospho-specific antibody (RB13311) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml.

Anti-RPS6KA3 / RSK2 Antibody (Ser369, AP) - LS-C282440 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RPS6KA3 / RSK2 Antibody (Ser369, APC) - LS-C282441 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RPS6KA3 / RSK2 Antibody (Ser369, FITC) - LS-C282446 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RPS6KA3 / RSK2 Antibody (Ser369, Biotin) - LS-C282444 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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