RPS6KA3

Gene Symbol	RPS6KA3
Entrez Gene	6197
Alt Symbol	CLS, HU-3, ISPK-1, MAPKAPK1B, MRX19, RSK, RSK2, S6K-alpha3, p90-RSK2, pp90RSK2
Species	Human
Gene Type	protein-coding
Description	ribosomal protein S6 kinase, 90kDa, polypeptide 3
Other Description	MAP kinase-activated protein kinase 1b|MAPK-activated protein kinase 1b|MAPKAP kinase 1b|MAPKAPK-1b|RSK-2|S6K-alpha-3|insulin-stimulated protein kinase 1|p90-RSK 3|ribosomal S6 kinase 2|ribosomal protein S6 kinase alpha-3
Swissprots	Q7Z3Z7 P51812 Q5JPK8 B2R9V4 Q59H26 Q4VAP3
Accessions	AAL87803 BAC80810 BAC80811 BAC80812 BAC80813 BAC80814 BAC80815 BAC80816 BAC80817 BAC80818 BAC80819 BAC80820 BAC80821 BAC80822 BAC80823 BAC80824 BAC80825 BAC80826 BAC80827 BAC80828 BAC80829 BAC80840 BAC80841 BAC80842 BAC80843 BAC80844 BAC80845 BAC80846 BAC80847 BAC80848 BAC80849 BAC80850 BAC80851 BAC80852 BAC80853 BAC80854 BAC80855 BAC80856 BAC80857 BAC80858 BAC80859 BAC80870 BAC80871 BAC80872 BAC80873 BAC80874 BAC80875 BAC80876 BAC80877 BAC80878 BAC80879 BAC80880 BAC80881 BAC80882 BAC80883 BAC80884 BAC80885 BAC80886 BAC80887 BAC80888 BAC80889 P51812 AA317826 AA858312 AB102662 BAC81131 AB208933 BAD92170 AK022869 AK294373 BAG57633 AK296775 BAG59354 AK313932 BAG36651 AK316482 BAH14853 AV684171 BC015451 BC096301 AAH96301 BC096302 AAH96302 BC096303 AAH96303 BQ427696 BU618685 CA843287 CA843526 CK905714 L07599 AAC82495 U08316 AAA81952 W00439 XM_005274573 XP_005274630 XM_005274577 XP_005274634 XM_006724507 XP_006724570 XM_011545555 XP_011543857 XM_011545556 XP_011543858 XM_011545557 XP_011543859 XM_011545558 XP_011543860 XM_011545559 XP_011543861 XM_011545560 XP_011543862 XM_011545561 XP_011543863 XM_011545562 XP_011543864 XM_011545563 XP_011543865 NM_004586 NP_004577
Function	Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at 'Ser-10', which results in the subsequent transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity. Phosphorylates RPS6 in response to serum or EGF via an mTOR- indepe
Subcellular Location	Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
Tissue Specificity	Expressed in many tissues, highest levels in skeletal muscle.
Top Pathways	Long-term potentiation, Progesterone-mediated oocyte maturation, MAPK signaling pathway, Neurotrophin signaling pathway, Oocyte meiosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Rsk 2 / MAPKAP Kinase 1b full length protein - ab60881 from Abcam Category Protein Prices $294.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Active human RSK2 (mutated L608 F) full length protein - ab172182 from Abcam Category Protein Prices $302.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human Rsk 2 / MAPKAP Kinase 1b full length protein - ab159428 from Abcam Category Protein Source Wheat germ Species Human

Human Rsk 2 / MAPKAP Kinase 1b protein fragment - ab159429 from Abcam Category Protein Source Wheat germ Species Human

Human Rsk 2 / MAPKAP Kinase 1b protein fragment - ab159430 from Abcam Category Protein Source Wheat germ Species Human

RPS6KA3 / RSK2 Antibody Blocking Peptide - LS-E7388 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RPS6KA3 / RSK2 Antibody Blocking Peptide - LS-E9385 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RSK2 Recombinant Protein - H00006197-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

RSK2 Partial Recombinant Protein - H00006197-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 2 µg Species Human

RSK2 Partial Recombinant Protein - H00006197-Q02 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human RSK2 Protein - P4247 from Novus Biologicals Category Protein Prices $549.00 Sizes 5 µg Source Insect Species Human

Recombinant RSK2 Protein - NBP1-99502 from Novus Biologicals Category Protein Prices $295.00 Sizes 5 µg Source Baculovirus (Sf9 insect cells)

RSK2 Peptide - P1596 from Novus Biologicals Category Peptide Species Human

RSK2 Peptide - P2930 from Novus Biologicals Category Peptide Species Human

RPS6KA3-Antibody-Center-S386-Blocking-Peptide - BP14787c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Phospho-RPS6KA3S369-Antibody-Blocking-peptide - BP3462a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

RSK2-RPS6KA3-Antibody-N-term-Blocking-peptide - BP7943b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RSK2-Antibody-C-term-Blocking-Peptide - BP7942b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RSK2 protein - 30R-2879 from Fitzgerald Category Protein Prices $250.00 Sizes 5 µg Source Sf-9 insect cells Species Human

RPS6KA3 / RSK2 - H00006197-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

RPS6KA3 / RSK2 - H00006197-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

RPS6KA3 / RSK2 - H00006197-Q01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

RPS6KA3 / RSK2 - H00006197-Q01-10 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Source in vitro transl. Species Human

RPS6KA3 / RSK2 - H00006197-Q01-25 from Acris Antibodies Category Protein Prices $520.00 Sizes 25 µg Source in vitro transl. Species Human

RPS6KA3 / RSK2 - H00006197-Q02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

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