| Gene Symbol |
WHAMM
|
| Entrez Gene |
123720
|
| Alt Symbol |
WHDC1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
WAS protein homolog associated with actin, golgi membranes and microtubules
|
| Other Description |
WAS protein homology region 2 domain-containing protein 1|WASP homolog-associated protein with actin, membranes and microtubules|WH2 domain-containing protein 1
|
| Swissprots |
Q8N1J9 Q8TF30
|
| Accessions |
EAW62438 Q8TF30 AB075851 BAB85557 AI377476 AK097947 BAC05201 AK126887 BC167774 AAI67774 XM_005272421 XP_005272478 XM_005272422 XP_005272479 XM_005272423 XP_005272480 XM_005272424 XP_005272481 XM_011521232 XP_011519534 XM_011521233 XP_011519535 NM_001080435 NP_001073904
|
| Function |
Acts as a nucleation-promoting factor (NPF) that stimulates Arp2/3-mediated actin polymerization both at the Golgi apparatus and along tubular membranes. Its activity in membrane tubulation requires F-actin and interaction with microtubules. Proposed to use coordinated actin-nucleating and microtubule- binding activities of distinct WHAMM molecules to drive membrane tubule elongation; when MT-bound can recruit and remodel membrane vesicles but is prevented to activate the Arp2/3 complex. Involved as a regulator of Golgi positioning and morphology. Participates in vesicle transport between the reticulum endoplasmic and the Golgi complex. Required for RhoD-dependent actin reorganization such as in cell adhesion and cell migration. {ECO:0000269|PubMed:18614018, ECO:0000269|PubMed:23027905, ECO:0000269|PubMed:23087206}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:18614018}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000269|PubMed:18614018}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:18614018}. Golgi apparatus, cis-Golgi network {ECO:0000269|PubMed:18614018}. Note=Localized to a perinuclear compartment near the microtubule-organizing center (MTOC). Also detected on tubulo-vesicular structures in the cell periphery that frequently localized along microtubules. {ECO:0000269|PubMed:18614018}.
|
| Tissue Specificity |
Expressed in brain, lung, heart, colon and kidney (at protein level).
|