WHAMM

Gene Symbol WHAMM
Entrez Gene 123720
Alt Symbol WHDC1
Species Human
Gene Type protein-coding
Description WAS protein homolog associated with actin, golgi membranes and microtubules
Other Description WAS protein homology region 2 domain-containing protein 1|WASP homolog-associated protein with actin, membranes and microtubules|WH2 domain-containing protein 1
Swissprots Q8N1J9 Q8TF30
Accessions EAW62438 Q8TF30 AB075851 BAB85557 AI377476 AK097947 BAC05201 AK126887 BC167774 AAI67774 XM_005272421 XP_005272478 XM_005272422 XP_005272479 XM_005272423 XP_005272480 XM_005272424 XP_005272481 XM_011521232 XP_011519534 XM_011521233 XP_011519535 NM_001080435 NP_001073904
Function Acts as a nucleation-promoting factor (NPF) that stimulates Arp2/3-mediated actin polymerization both at the Golgi apparatus and along tubular membranes. Its activity in membrane tubulation requires F-actin and interaction with microtubules. Proposed to use coordinated actin-nucleating and microtubule- binding activities of distinct WHAMM molecules to drive membrane tubule elongation; when MT-bound can recruit and remodel membrane vesicles but is prevented to activate the Arp2/3 complex. Involved as a regulator of Golgi positioning and morphology. Participates in vesicle transport between the reticulum endoplasmic and the Golgi complex. Required for RhoD-dependent actin reorganization such as in cell adhesion and cell migration. {ECO:0000269|PubMed:18614018, ECO:0000269|PubMed:23027905, ECO:0000269|PubMed:23087206}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:18614018}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000269|PubMed:18614018}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:18614018}. Golgi apparatus, cis-Golgi network {ECO:0000269|PubMed:18614018}. Note=Localized to a perinuclear compartment near the microtubule-organizing center (MTOC). Also detected on tubulo-vesicular structures in the cell periphery that frequently localized along microtubules. {ECO:0000269|PubMed:18614018}.
Tissue Specificity Expressed in brain, lung, heart, colon and kidney (at protein level).

WHDC1 (K-13) - sc-136951 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
WHDC1 (K-13): sc-136951. Western blot analysis of WHDC1 expression in IMR-32 (A) and SH-SY5Y (B) whole cell lysates.

WHDC1 (S-14) - sc-136954 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
WHDC1 (S-14): sc-136954. Western blot analysis of WHDC1 expression in SH-SY5Y whole cell lysate.

Anti-WHAMM antibody - ab122572 from Abcam

Prices $443.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab122572, at 1/200 dilution, staining WHAMM in paraffin-embedded Human hippocampus tissue by Immunohistochemistry.

Anti-WHAMM antibody - ab122639 from Abcam

Prices $443.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab122639, at 1/5, staining WHAMM in paraffin embedded Human lateral ventricle tissue by Immunohistochemistry.

Anti-WHAMM antibody - C-terminal - ab135414 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-WHAMM antibody - C-terminal (ab135414) at 1 µg/ml + Placenta lysate at 10 µg

Anti-WHAMM Antibody (aa599-648) - LS-C152158 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
WHAMM antibody Western Blot of Placenta.

WHAMM Antibody - NBP1-89592 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: WHAMM Antibody [NBP1-89592] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG sp

WHAMM Antibody - NBP1-89593 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: WHAMM Antibody [NBP1-89593] - Staining of human cell line U-2 OS shows positivity in cytoplasm.

Anti-WHAMM antibody produced in rabbit - HPA040231 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-WHAMM: <B>Cat. No. HPA040231</B>: Immunohistochemical staining of human lateral ventricle shows strong cytoplasmic positivity in neuronal cells.

Anti-WHAMM antibody produced in rabbit - HPA039690 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-WHAMM: <B>Cat. No. HPA039690</B>: Immunohistochemical staining of human hippocampus shows strong cytoplasmic positivity in neuronal cells.

WHAMM Antibody - C-terminal region (ARP66308_P050) - ARP66308_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

WHAMM antibody - H00123720-B01P from Acris Antibodies

Prices $1,530.00
Sizes 500 µg
Host Mouse
Clonality Polyclonal

Anti-WHAMM (aa 660-748) polyclonal antibody - DPABH-20877 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Anti-WHAMM (aa 439-511) polyclonal antibody - DPABH-20946 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Anti-WHAMM (aa 599-648) polyclonal antibody - DPABH-26054 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Anti-Whamm Antibody - ABT60 from EMD Millipore

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

WHAMM-Antibody-C-terminal-region-AI15324 - AI15324 from Abgent, a WuXi AppTec company

Prices $293.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
WB Suggested Anti-WHAMM Antibody Titration: 1.0 ug/ml Positive Control: Placenta

Whamm antibody - AP56112PU-N from Acris Antibodies

Prices $380.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry Analysis: Representative lot data. Paraffin-embedded fibromuscular stroma of human prostate (figure 1) and distal and proximal convoluted tubules in human kidney (figure 2) tissues were prepared using heat-induced epitope retrieval in citrate buffer, pH 6.0. Immunostaining was performed using a 1:500 dilution of Cat. No. AP56112PU-N, Anti-Whamm. Reactivity was detected using the IHC-Select® Detection Kit. Positive cytoplasmic staining.

Anti-Whamm Antibody - ABT60 from Sigma-Aldrich

Prices $319.00
Sizes abt60
Clonality Polyclonal
Immunocytochemistry: <br />Representative lot data. <br />Confocal fluorescent analysis of NIH/3T3 cells using ABT60 (Red). Actin filaments have been labeled with AlexaFluor®488 -Phalloidin (Green). Nucleus is stained with DAPI (Blue). This antibody positively stains cytoplasm and membrane. The staining pattern is as expected: stains the membrane/cytoplasm, including ER, Golgi, etc,. Staining is also localized to a perinuclear compartment near the microtubule-organizing center (MTOC). Staining is also detected in tubulo-vesicular structures in the cell periphery that frequently localized along microtubules.

WHAMM antibody - TA331240 from Acris Antibodies

Prices $325.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
WB Suggested Anti-WHAMM Antibody; Titration: 1.0 ug/ml; Positive Control: Placenta

Anti-WHAMM (C-terminal) Produced in rabbit - SAB4200590 from Sigma-Aldrich

Prices $347.00
Sizes 200 µl
Host Rabbit

Anti-WHAMM antibody produced in rabbit - SAB4200589 from Sigma-Aldrich

Prices $347.00
Sizes 200 µl
Host Rabbit

Anti-WHAMM Antibody A08858 - A08858 from Boster Bio

Prices $299.00
Sizes 1
Host Rabbit
Clonality Polyclonal

WHAMM Antibody - C-terminal region : Biotin (ARP66308_P050-Biotin) - ARP66308_P050-Biotin from Aviva Systems Biology

Host Rabbit
Clonality Polyclonal

WHAMM Antibody - C-terminal region : FITC (ARP66308_P050-FITC) - ARP66308_P050-FITC from Aviva Systems Biology

Host Rabbit
Clonality Polyclonal
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