| Gene Symbol |
MED12
|
| Entrez Gene |
9968
|
| Alt Symbol |
ARC240, CAGH45, FGS1, HOPA, MED12S, OHDOX, OKS, OPA1, TNRC11, TRAP230
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mediator complex subunit 12
|
| Other Description |
CAG repeat protein 45|OPA-containing protein|activator-recruited cofactor 240 kDa component|human opposite paired|mediator of RNA polymerase II transcription subunit 12|mediator of RNA polymerase II transcription, subunit 12 homolog|putative mediator subunit 12|thyroid hormone receptor-associated protein complex 230 kDa component|thyroid hormone receptor-associated protein, 230 kDa subunit|trinucleotide repeat containing 11 (THR-associated protein, 230 kDa subunit)|trinucleotide repeat-containing gene 11 protein
|
| Swissprots |
Q93074 Q9UND7 Q9UHV6 O75557 O15410
|
| Accessions |
AAD44162 BAC81020 BAC81021 BAC81022 BAC81023 BAC81024 BAC81025 BAC81026 BAC81027 BAC81028 BAC81029 BAC81030 BAC81031 BAC81032 BAC81033 BAC81034 BAC81035 BAC81036 BAC81037 BAC81038 BAC81039 BAC81050 BAC81051 BAC81052 BAC81053 BAC81054 BAC81055 BAC81056 BAC81057 BAC81058 BAC81059 BAC81060 BAC81061 BAC81062 BAC81063 BAC81064 BAC81065 BAC81066 BAC81067 BAC81068 BAC81069 BAC81080 BAC81081 BAC81082 BAC81083 BAC81084 BAC81085 BAC81086 BAC81087 BAC81088 BAC81089 BAC81090 BAC81091 BAC81092 BAC81093 BAC81094 BAC81095 BAC81096 BAC81097 BAC81098 BAC81099 EAX05314 EAX05315 EAX05316 EAX05317 EAX05318 Q93074 AB102668 BAC81137 AF071309 AAC83163 AJ306428 CAC84084 AK302543 BAG63815 BC127264 BC156136 AAI56137 BC156978 AAI56979 BM662470 D83783 BAA12112 DB069668 FN430679 CAZ90628 U23863 U80742 AAB91440 XM_005262317 XP_005262374 XM_005262319 XP_005262376 NM_005120 NP_005111
|
| Function |
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. {ECO:0000269|PubMed:16565090, ECO:0000269|PubMed:16595664, ECO:0000269|PubMed:17000779}.
|
| Subcellular Location |
Nucleus {ECO:0000305}.
|
| Tissue Specificity |
Ubiquitous. {ECO:0000269|PubMed:10198638}.
|