MED12

Gene Symbol MED12
Entrez Gene 9968
Alt Symbol ARC240, CAGH45, FGS1, HOPA, MED12S, OHDOX, OKS, OPA1, TNRC11, TRAP230
Species Human
Gene Type protein-coding
Description mediator complex subunit 12
Other Description CAG repeat protein 45|OPA-containing protein|activator-recruited cofactor 240 kDa component|human opposite paired|mediator of RNA polymerase II transcription subunit 12|mediator of RNA polymerase II transcription, subunit 12 homolog|putative mediator subunit 12|thyroid hormone receptor-associated protein complex 230 kDa component|thyroid hormone receptor-associated protein, 230 kDa subunit|trinucleotide repeat containing 11 (THR-associated protein, 230 kDa subunit)|trinucleotide repeat-containing gene 11 protein
Swissprots Q93074 Q9UND7 Q9UHV6 O75557 O15410
Accessions AAD44162 BAC81020 BAC81021 BAC81022 BAC81023 BAC81024 BAC81025 BAC81026 BAC81027 BAC81028 BAC81029 BAC81030 BAC81031 BAC81032 BAC81033 BAC81034 BAC81035 BAC81036 BAC81037 BAC81038 BAC81039 BAC81050 BAC81051 BAC81052 BAC81053 BAC81054 BAC81055 BAC81056 BAC81057 BAC81058 BAC81059 BAC81060 BAC81061 BAC81062 BAC81063 BAC81064 BAC81065 BAC81066 BAC81067 BAC81068 BAC81069 BAC81080 BAC81081 BAC81082 BAC81083 BAC81084 BAC81085 BAC81086 BAC81087 BAC81088 BAC81089 BAC81090 BAC81091 BAC81092 BAC81093 BAC81094 BAC81095 BAC81096 BAC81097 BAC81098 BAC81099 EAX05314 EAX05315 EAX05316 EAX05317 EAX05318 Q93074 AB102668 BAC81137 AF071309 AAC83163 AJ306428 CAC84084 AK302543 BAG63815 BC127264 BC156136 AAI56137 BC156978 AAI56979 BM662470 D83783 BAA12112 DB069668 FN430679 CAZ90628 U23863 U80742 AAB91440 XM_005262317 XP_005262374 XM_005262319 XP_005262376 NM_005120 NP_005111
Function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. {ECO:0000269|PubMed:16565090, ECO:0000269|PubMed:16595664, ECO:0000269|PubMed:17000779}.
Subcellular Location Nucleus {ECO:0000305}.
Tissue Specificity Ubiquitous. {ECO:0000269|PubMed:10198638}.

MED12 Antibody - 4529 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using MED12 Antibody.

MED12 (D9K5J) Rabbit mAb - 14360 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D9K5J
Western blot analysis of extracts from various cell lines using MED12 (D9K5J) Rabbit mAb.

TRAP230 (A-18) - sc-5374 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TRAP230 (A-18): sc-5374. Immunoperoxidase staining of formalin fixed, paraffin-embedded human bone marrow tissue showing nuclear and cytoplasmic staining of hematopoietic cells.

TRAP230 (H-80) - sc-366365 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

TRAP230 (R-17) - sc-5375 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

TRAP230 (S-19) - sc-5372 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TRAP230 (S-19): sc-5372. Immunoperoxidase staining of formalin fixed, paraffin-embedded human bone marrow tissue showing nuclear and cytoplasmic staining of subset of hematopoietic cells.

Anti-MED12 Antibody (aa1981-1994) - LS-C186546 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-MED12 Antibody (C-Terminus) - LS-C287631 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human MED12 by Immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-MED12 used at a dilution of 1:1000 (1 Detection: DAB.

Anti-MED12 Antibody (C-Terminus) - LS-C285954 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Mouse MED12 by Immunohistochemistry. Sample: FFPE section of mouse squamous cell carcinoma. Antibody: Affinity purified rabbit anti-MED12 used at a dilution of 1:250.

Anti-MED12 Antibody (C-Terminus) - LS-C72341 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MED12 Antibody (aa611-660) - LS-C119196 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

MED12 Antibody - NB100-2357 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: MED12 Antibody [NB100-2357] - Detection of Human and Mouse Med12 by Western Blot. Samples: Whole cell lysate (50 ug) from HeLa and mouse NIH3T3 cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-Med12 antibody NB100-2357 used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.

MED12 Antibody - NBP1-86670 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: MED12 Antibody [NBP1-86670] - Staining of human rectum shows strong nuclear positivity in glandular cells.

MED12 Antibody - NBP1-86669 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

MED12 Antibody - H00009968-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: MED12 Antibody [H00009968-A01] - Western Blot detection against Immunogen (38.54 KDa).

Anti-MED12 antibody produced in rabbit - HPA003185 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-MED12: <B>Cat. No. HPA003185</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human bone marrow tissue showing nuclear staining of bone marrow poetic cells..

Anti-MED12 antibody produced in rabbit - HPA003184 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-MED12: <B>Cat. No. HPA003184</B>: Immunohistochemical staining of human bone marrow shows strong nuclear positivity in hematopoietic cells.

MED12-aa1981-1994-Antibody-internal-region-near-C-Term - AF3571a from Abgent, a WuXi AppTec company

Prices $325.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

MED12 Antibody (OAAF02597) - OAAF02597 from Aviva Systems Biology

Prices $289.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Goat anti-MED12 (aa1981-1994) middle region (near C-terminal region) Antibody (OAEB02823) - OAEB02823 from Aviva Systems Biology

Prices $229.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

MED12 antibody - 70R-18459 from Fitzgerald

Prices $375.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
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