| Gene Symbol |
STRA13
|
| Entrez Gene |
201254
|
| Alt Symbol |
CENP-X, CENPX, D9, FAAP10, MHF2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
stimulated by retinoic acid 13
|
| Other Description |
FANCM-interacting histone fold protein 2|Fanconi anemia-associated polypeptide of 10 kDa|centromere protein X|retinoic acid-inducible gene D9 protein homolog|stimulated by retinoic acid 13 homolog|stimulated by retinoic acid gene 13 protein homolog
|
| Swissprots |
O00281 Q96F51 O00282 Q96DD4 A8MT69
|
| Accessions |
A8MT69 CAI93454 BC009571 AAH09571 BC011610 AAH11610 BI837753 BQ648002 CB110145 DQ893089 ABM84015 DQ896361 ABM87360 HY110543 U95006 AAB53638 U95007 AAB53639 XM_005256339 XP_005256396 NM_001271006 NP_001257935 NM_001271007 NP_001257936 NM_144998 NP_659435
|
| Function |
DNA-binding component of the FA core complex involved in DNA damage repair and genome maintenance. Recruited to forks stalled by DNA interstrand cross-links, and required for cellular resistance to such lesions. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. Component of the APITD1/CENPS complex that is essential for the stable assembly of the outer kinetochore. Plays an important role in mitotic progression and chromosome segregation. {ECO:0000269|PubMed:19620631, ECO:0000269|Ref.5, ECO:0000269|Ref.6}.
|
| Subcellular Location |
Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Constitutively localizes to centromeres throughout the cell cycle, and to kinetochores during mitosis.
|
| Top Pathways |
Fanconi anemia pathway
|
![Western Blot: STRA13 Overexpression Lysate (Adult Normal) [NBL1-16565] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for STRA13.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7875_STRA13%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-16565-img0002.jpg)