Gene Symbol | STRA13 |
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Entrez Gene | 201254 |
Alt Symbol | CENP-X, CENPX, D9, FAAP10, MHF2 |
Species | Human |
Gene Type | protein-coding |
Description | stimulated by retinoic acid 13 |
Other Description | FANCM-interacting histone fold protein 2|Fanconi anemia-associated polypeptide of 10 kDa|centromere protein X|retinoic acid-inducible gene D9 protein homolog|stimulated by retinoic acid 13 homolog|stimulated by retinoic acid gene 13 protein homolog |
Swissprots | O00281 Q96F51 O00282 Q96DD4 A8MT69 |
Accessions | A8MT69 CAI93454 BC009571 AAH09571 BC011610 AAH11610 BI837753 BQ648002 CB110145 DQ893089 ABM84015 DQ896361 ABM87360 HY110543 U95006 AAB53638 U95007 AAB53639 XM_005256339 XP_005256396 NM_001271006 NP_001257935 NM_001271007 NP_001257936 NM_144998 NP_659435 |
Function | DNA-binding component of the FA core complex involved in DNA damage repair and genome maintenance. Recruited to forks stalled by DNA interstrand cross-links, and required for cellular resistance to such lesions. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. Component of the APITD1/CENPS complex that is essential for the stable assembly of the outer kinetochore. Plays an important role in mitotic progression and chromosome segregation. {ECO:0000269|PubMed:19620631, ECO:0000269|Ref.5, ECO:0000269|Ref.6}. |
Subcellular Location | Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Constitutively localizes to centromeres throughout the cell cycle, and to kinetochores during mitosis. |
Top Pathways | Fanconi anemia pathway |
Stra13 CRISPR/Cas9 KO Plasmid (h) - sc-416245 from Santa Cruz Biotechnology
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Stra13 HDR Plasmid (h) - sc-416245-HDR from Santa Cruz Biotechnology
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Stra13 Double Nickase Plasmid (h) - sc-416245-NIC from Santa Cruz Biotechnology
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Stra13 Double Nickase Plasmid (h2) - sc-416245-NIC-2 from Santa Cruz Biotechnology
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Stra13 CRISPR Activation Plasmid (h) - sc-416245-ACT from Santa Cruz Biotechnology
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Stra13 CRISPR Activation Plasmid (h2) - sc-416245-ACT-2 from Santa Cruz Biotechnology
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Stra13 Lentiviral Activation Particles (h) - sc-416245-LAC from Santa Cruz Biotechnology
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Stra13 Lentiviral Activation Particles (h2) - sc-416245-LAC-2 from Santa Cruz Biotechnology
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Stra13 siRNA (h) - sc-93558 from Santa Cruz Biotechnology
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Stra13 shRNA Plasmid (h) - sc-93558-SH from Santa Cruz Biotechnology
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Stra13 shRNA (h) Lentiviral Particles - sc-93558-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU007011 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20761 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20761 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04436 from Sigma-Aldrich
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STRA13 siRNA (Human) - CRJ6285 from Cohesion Biosciences
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STRA13 - MBS8224591 from MyBioSource
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shRNA set against Human STRA13 (NM_144998.3) - SHH420076 from Creative biogene
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STRA13 shRNA Plasmid (Human) - CHJ6285 from Cohesion Biosciences
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STRA13 miRNA 3'UTR clone - MiUTR3H-16181 from Creative biogene
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