SEMA4D

Gene Symbol	SEMA4D
Entrez Gene	10507
Alt Symbol	C9orf164, CD100, M-sema-G, SEMAJ, coll-4
Species	Human
Gene Type	protein-coding
Description	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
Other Description	A8|BB18|GR3|sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, 4D|semaphorin-4D
Swissprots	Q8N8B0 B2RPM6 Q7Z5S4 Q92854
Accessions	EAW62765 EAW62766 EAW62767 EAW62768 EAW62769 EAW62770 EAW62771 EAW62772 Q92854 AB210030 BAE06112 AI055975 AJ420442 AK090804 AK091601 AK097056 BAC04938 AK128342 AK293749 BAG57171 AK316107 BAH14478 BC054500 AAH54500 BC137515 AAI37516 BC137518 AAI37519 BX648216 DT220478 U60800 AAC50810 XM_005251654 XP_005251711 XM_011518123 XP_011516425 XM_011518124 XP_011516426 XM_011518125 XP_011516427 XM_011518126 XP_011516428 XM_011518127 XP_011516429 XM_011518128 XP_011516430 XM_011518129 XP_011516431 XM_011518130 XP_011516432 XM_011518131 XP_011516433 XM_011518132 XP_011516434 XM_011518133 XP_011516435 XM_011518134 XP_011516436 XM_011518135 XP_011516437 XM_011518136 XP_011516438 XM_011518137 XP_011516439 XR_242562 XR_929702 NM_182635 NM_001142287 NP_001135759 NM_006378 NP_006369
Function	Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system. Regulates dendrite and axon branching and morphogenesis. Promotes the migration of cerebellar granule cells and of endothelial cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro). Promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Interaction with PLXNB1 mediates activation of RHOA. {ECO:0000269|PubMed:16055703, ECO:0000269|PubMed:19788569, ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:8876214}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:8876214}; Single-pass type I membrane protein {ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:8876214}.
Tissue Specificity	Strongly expressed in skeletal muscle, peripheral blood lymphocytes, spleen, and thymus and also expressed at lower levels in testes, brain, kidney, small intestine, prostate, heart, placenta, lung and pancreas, but not in colon and liver. {ECO:0000269|PubMed:8876214}.
Top Pathways	Axon guidance

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SEMA4D / Semaphorin 4D / CD100 ELISA Kit (Sandwich ELISA) - LS-F7966 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 0.61 ng/ml Range 1.56-100 ng/ml

Semaphorin 4D (SEMA4D), Human, ELISA Kit - SEB430Hu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Sensitivity 0.64ng/mL Range 1.56-100ng/mL

Semaphorin-4D, Human, ELISA Kit - E01S0300 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 1.0ng/ml Range 5.0-100ng/mL,

Semaphorin-4D, SEMA4D, Human, ELISA Kit - E2275h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t

Soluble Cluster of differentiation 100 (sCD100), Human, ELISA Kit - CSB-E15792h from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 31.25 pg/ml Range 125 pg/ml-8000 pg/ml

Cluster of Differentiation 100, CD100, Mouse, ELISA Kit - E-EL-M0301 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Human SEMA4D ELISA Kit - HS0307 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine SEMA4D/CD100 ELISA Kit - AS0307 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Cluster of differentiation 100, ELISA Kit - MBS725813 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 ng/mL.

Cluster of differentiation 100, ELISA Kit - MBS729397 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 ng/mL.

Cluster of differentiation 100, ELISA Kit - MBS746578 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Cluster of differentiation 100, ELISA Kit - MBS752996 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cluster of differentiation 100, ELISA Kit - MBS721775 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cluster of differentiation 100, ELISA Kit - MBS750971 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cluster of differentiation 100, ELISA Kit - MBS750217 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 ng/mL.

Cluster of differentiation 100, ELISA Kit - MBS745886 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cluster of differentiation 100, ELISA Kit - MBS733091 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Cluster of differentiation 100, ELISA Kit - MBS726455 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cluster of differentiation 100, ELISA Kit - MBS750777 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cluster of differentiation 100, ELISA Kit - MBS749000 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

sema domain, immunoglobulin domain (Ig) , transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D, ELISA Kit - MBS705483 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 31.25 pg/ml. Range 125 pg/ml -8000 pg/ml.

SEMA4D, ELISA Kit - MBS2515796 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.188ng/mL Range 0.313-20ng/mL

Semaphorin 4D, ELISA Kit - MBS739027 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,850.00, $5,340.00 Sizes 48 -strip-wells- (Competitive), 96 -strip-wells- (Competitive), 5x96-strip-wells- (Competitive), 10x96-strip-wells- (Competitive) Sensitivity 0.1 ng/mL.

Semaphorin 4D (SEMA4D), ELISA Kit - MBS2023012 from MyBioSource Category ELISA Kit Prices $355.00, $540.00, $730.00, $2,985.00, $5,410.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.57ng/mL. Range 1.56-100ng/mL.

Semaphorin-4D, ELISA Kit - MBS011525 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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