SEMA4D

Gene Symbol	SEMA4D
Entrez Gene	10507
Alt Symbol	C9orf164, CD100, M-sema-G, SEMAJ, coll-4
Species	Human
Gene Type	protein-coding
Description	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
Other Description	A8|BB18|GR3|sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, 4D|semaphorin-4D
Swissprots	Q8N8B0 B2RPM6 Q7Z5S4 Q92854
Accessions	EAW62765 EAW62766 EAW62767 EAW62768 EAW62769 EAW62770 EAW62771 EAW62772 Q92854 AB210030 BAE06112 AI055975 AJ420442 AK090804 AK091601 AK097056 BAC04938 AK128342 AK293749 BAG57171 AK316107 BAH14478 BC054500 AAH54500 BC137515 AAI37516 BC137518 AAI37519 BX648216 DT220478 U60800 AAC50810 XM_005251654 XP_005251711 XM_011518123 XP_011516425 XM_011518124 XP_011516426 XM_011518125 XP_011516427 XM_011518126 XP_011516428 XM_011518127 XP_011516429 XM_011518128 XP_011516430 XM_011518129 XP_011516431 XM_011518130 XP_011516432 XM_011518131 XP_011516433 XM_011518132 XP_011516434 XM_011518133 XP_011516435 XM_011518134 XP_011516436 XM_011518135 XP_011516437 XM_011518136 XP_011516438 XM_011518137 XP_011516439 XR_242562 XR_929702 NM_182635 NM_001142287 NP_001135759 NM_006378 NP_006369
Function	Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system. Regulates dendrite and axon branching and morphogenesis. Promotes the migration of cerebellar granule cells and of endothelial cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro). Promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Interaction with PLXNB1 mediates activation of RHOA. {ECO:0000269|PubMed:16055703, ECO:0000269|PubMed:19788569, ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:8876214}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:8876214}; Single-pass type I membrane protein {ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:8876214}.
Tissue Specificity	Strongly expressed in skeletal muscle, peripheral blood lymphocytes, spleen, and thymus and also expressed at lower levels in testes, brain, kidney, small intestine, prostate, heart, placenta, lung and pancreas, but not in colon and liver. {ECO:0000269|PubMed:8876214}.
Top Pathways	Axon guidance

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Semaphorin 4D protein fragment - ab168894 from Abcam Category Protein Prices $352.00 Sizes 100 µg Source HEK 293 cells Species Human

Human Semaphorin 4D peptide - ab39827 from Abcam Category Peptide

Human Semaphorin 4D protein fragment - ab153091 from Abcam Category Protein Source Wheat germ Species Human

Human Semaphorin 4D protein fragment - ab97413 from Abcam Category Protein Source CHO Species Human

Human Semaphorin 4D protein fragment - ab192291 from Abcam Category Protein Source HEK 293 cells Species Human

SEMA4D / Semaphorin 4D / CD100 Antibody Blocking Peptide - LS-E22481 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Semaphorin 4D/CD100 Protein - H00010507-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

sCD100 Recombinant Protein - GTX48079-PRO from GeneTex Category Protein Prices $329.00 Sizes 20 μg Source Hamster Species Human

Recombinant Human Semaphorin 4D Fc Chimera, CF - 7470-S4-050 from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived

Human CD100 protein - orb84199 from Biorbyt Category Protein Prices $323.00, $527.00 Sizes 20 μg, 50 μg Source Human Species Human

Human CD100 protein - orb180404 from Biorbyt Category Protein Prices $306.00, $451.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Source HEK293 Species Human

Human CD100 (HEK) protein - orb191073 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source HEK293 cells Species Human

Cynomolgus CD100 protein - orb139644 from Biorbyt Category Protein Prices $196.00, $323.00, $1,063.00 Sizes 5 μg, 20 μg, 100 μg Source Human Cells

Mouse CD100 protein - orb84114 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Mouse Species Human

CD100 / SEMA4D (sCD100) - AR09437PU-N from Acris Antibodies Category Protein Prices $235.00 Sizes 20 µg Source CHO cells Species Human

CD100 / SEMA4D (sCD100) - AR09437PU-S from Acris Antibodies Category Protein Prices $135.00 Sizes 5 µg Source CHO cells Species Human

CD100 / SEMA4D - AR31164PU-N from Acris Antibodies Category Protein Prices $320.00 Sizes 20 µg Source CHO cells Species Human

CD100 / SEMA4D - H00010507-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CD100 / SEMA4D - H00010507-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CD100 / SEMA4D - P6140 from Acris Antibodies Category Protein Prices $580.00 Sizes 20 µg Species Human

sCD100, Human, Recombinant - 28-10102 from ARP American Research Products Category Protein Prices $99.00, $104.00, $199.00 Sizes 5 µg, 1 mg, 20 µg Source CHO cells Species Human

Semaphorin 4D (SEMA4D), Human - 20-7706 from ARP American Research Products Category Protein Prices $479.00 Sizes 50 µg Source E.coli Species Human

sCD100 Recombinant Protein - 40-530 from ProSci Category Protein Prices $130.00, $225.00 Sizes 5 µg, 20 µg Source CHO cells

SEMA4D Recombinant Protein - 96-090 from ProSci Category Protein Prices $375.00 Sizes 100 µg Source HEK293 cells Species Human

CD100 fusion protein - Ag5769 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

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