| Gene Symbol |
SEMA4D
|
| Entrez Gene |
10507
|
| Alt Symbol |
C9orf164, CD100, M-sema-G, SEMAJ, coll-4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
|
| Other Description |
A8|BB18|GR3|sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, 4D|semaphorin-4D
|
| Swissprots |
Q8N8B0 B2RPM6 Q7Z5S4 Q92854
|
| Accessions |
EAW62765 EAW62766 EAW62767 EAW62768 EAW62769 EAW62770 EAW62771 EAW62772 Q92854 AB210030 BAE06112 AI055975 AJ420442 AK090804 AK091601 AK097056 BAC04938 AK128342 AK293749 BAG57171 AK316107 BAH14478 BC054500 AAH54500 BC137515 AAI37516 BC137518 AAI37519 BX648216 DT220478 U60800 AAC50810 XM_005251654 XP_005251711 XM_011518123 XP_011516425 XM_011518124 XP_011516426 XM_011518125 XP_011516427 XM_011518126 XP_011516428 XM_011518127 XP_011516429 XM_011518128 XP_011516430 XM_011518129 XP_011516431 XM_011518130 XP_011516432 XM_011518131 XP_011516433 XM_011518132 XP_011516434 XM_011518133 XP_011516435 XM_011518134 XP_011516436 XM_011518135 XP_011516437 XM_011518136 XP_011516438 XM_011518137 XP_011516439 XR_242562 XR_929702 NM_182635 NM_001142287 NP_001135759 NM_006378 NP_006369
|
| Function |
Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system. Regulates dendrite and axon branching and morphogenesis. Promotes the migration of cerebellar granule cells and of endothelial cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro). Promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Interaction with PLXNB1 mediates activation of RHOA. {ECO:0000269|PubMed:16055703, ECO:0000269|PubMed:19788569, ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:8876214}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:8876214}; Single-pass type I membrane protein {ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:8876214}.
|
| Tissue Specificity |
Strongly expressed in skeletal muscle, peripheral blood lymphocytes, spleen, and thymus and also expressed at lower levels in testes, brain, kidney, small intestine, prostate, heart, placenta, lung and pancreas, but not in colon and liver. {ECO:0000269|PubMed:8876214}.
|
| Top Pathways |
Axon guidance
|
