| Gene Symbol |
CLEC5A
|
| Entrez Gene |
23601
|
| Alt Symbol |
CLECSF5, MDL-1, MDL1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
C-type lectin domain family 5, member A
|
| Other Description |
C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 5|C-type lectin domain family 5 member A|C-type lectin superfamily member 5|myeloid DAP12-associating lectin 1|myeloid DAP12-associating lectin-1
|
| Swissprots |
Q9UKQ0 Q52M11 Q9NY25
|
| Accessions |
AAS07444 EAL24012 EAW83991 EAW83992 Q9NY25 AF139768 AAF02491 AI418484 AJ271684 CAB71334 AK292766 BAF85455 AK295200 BAG58199 AK307095 AK313703 BAG36449 BC093714 AAH93714 BC112099 AAI12100 BC113098 AAI13099 BC113099 AAI13100 BC143392 BQ005467 BQ446122 XM_011515995 XP_011514297 XR_927428 NM_001301167 NP_001288096 NM_013252 NP_037384
|
| Function |
Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. Acts as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation (By similarity). Critical macrophage receptor for dengue virus serotypes 1-4. The binding of dengue virus to CLEC5A triggers signaling through the phosphylation of TYROBP, this interaction does not result in viral entry, but stimulates proinflammatory cytokine release. {ECO:0000250, ECO:0000269|PubMed:10449773, ECO:0000269|PubMed:18496526}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:21566123}; Single-pass type II membrane protein {ECO:0000269|PubMed:21566123}.
|
| Tissue Specificity |
Expressed in peripheral blood monocytes and in the monocyte/macrophage cell lines U-937 and Mono-Mac-6, but not in cell lines of other origins. Expression is down-regulated when monocytes differentiate into dendritic cells. {ECO:0000269|PubMed:10449773}.
|