CLEC5A

Gene Symbol	CLEC5A
Entrez Gene	23601
Alt Symbol	CLECSF5, MDL-1, MDL1
Species	Human
Gene Type	protein-coding
Description	C-type lectin domain family 5, member A
Other Description	C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 5|C-type lectin domain family 5 member A|C-type lectin superfamily member 5|myeloid DAP12-associating lectin 1|myeloid DAP12-associating lectin-1
Swissprots	Q9UKQ0 Q52M11 Q9NY25
Accessions	AAS07444 EAL24012 EAW83991 EAW83992 Q9NY25 AF139768 AAF02491 AI418484 AJ271684 CAB71334 AK292766 BAF85455 AK295200 BAG58199 AK307095 AK313703 BAG36449 BC093714 AAH93714 BC112099 AAI12100 BC113098 AAI13099 BC113099 AAI13100 BC143392 BQ005467 BQ446122 XM_011515995 XP_011514297 XR_927428 NM_001301167 NP_001288096 NM_013252 NP_037384
Function	Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. Acts as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation (By similarity). Critical macrophage receptor for dengue virus serotypes 1-4. The binding of dengue virus to CLEC5A triggers signaling through the phosphylation of TYROBP, this interaction does not result in viral entry, but stimulates proinflammatory cytokine release. {ECO:0000250, ECO:0000269|PubMed:10449773, ECO:0000269|PubMed:18496526}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:21566123}; Single-pass type II membrane protein {ECO:0000269|PubMed:21566123}.
Tissue Specificity	Expressed in peripheral blood monocytes and in the monocyte/macrophage cell lines U-937 and Mono-Mac-6, but not in cell lines of other origins. Expression is down-regulated when monocytes differentiate into dendritic cells. {ECO:0000269|PubMed:10449773}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CLEC5A full length protein - ab132716 from Abcam Category Protein Source Wheat germ Species Human

Human CLEC5A peptide - ab87123 from Abcam Category Peptide

Human CLEC5A protein fragment - ab202186 from Abcam Category Protein Source E. coli Species Human

CLEC5A / MDL-1 Antibody Blocking Peptide - LS-E22686 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MDL-1/CLEC5A Recombinant Protein - H00023601-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human MDL-1/CLEC5A, CF - 8544-CL-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Tyr26-Lys188, with an N-terminal 9-His tag

Cynomolgus CLEC5A/MDL1 protein - orb138577 from Biorbyt Category Protein Prices $417.00, $859.00 Sizes 20 μg, 100 μg Source Human Cells

Cynomolgus CLEC5A/MDL1 protein - orb138575 from Biorbyt Category Protein Prices $323.00, $646.00 Sizes 20 μg, 100 μg Source Human Cells

CLEC5A protein (His tag) - 80R-4080 from Fitzgerald Category Protein Prices $275.00 Sizes 50 µg Source E.coli

CLEC5A (28-188, His-tag) - AR51766PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 250 µg Source E. coli Species Human

CLEC5A (28-188, His-tag) - AR51766PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 50 µg Source E. coli Species Human

CLEC5A - H00023601-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

CLEC5A - H00023601-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

CLEC5A fusion protein - Ag13030 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

CLEC5A fusion protein - ag13025 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human CLEC5A, His-tagged - CLEC5A-11321H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human C-type lectin domain family 5 member A(CLEC5A) - CSB-YP873686HU CSB-EP873686HU CSB-BP873686HU CSB-MP873686HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

CLEC5A, 28-188aa, Human, His tag, E.coli (Denatured) - ATGP2946 from ATGen Category Protein Prices $80.00, $240.00, $720.00 Sizes 10 µg, 50 µg, 250 µg Species Human

Recombinant Human MDL-1/CLEC5A Protein, CF - 8544-CL from R&D Systems Category Protein Prices $329.00 Sizes 50 µg Source Mouse myeloma cell line, NS0-derived Tyr26-Lys188, with an N-terminal 9-His tag Species Human

C-type lectin domain family 5 member A (CLEC5A), Recombinant Protein - MBS1392350 from MyBioSource Category Protein Prices $935.00, $935.00, $1,160.00, $1,160.00, $1,400.00, $1,400.00, $1,855.00, $1,855.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

CLEC5A Peptide, Human - M34GP03274H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Human MDL-1/CLEC5A Protein - NBP2-51953 from Novus Biologicals Category Protein Prices $259.00, $759.00 Sizes 50 µg, 250 µg Source E. coli Species Human

CLEC5A - PAT-83085-2 from Nordic BioSite Category Protein Species Human

CLEC5A - PAT-83085-1 from Nordic BioSite Category Protein Species Human

C-Type Lectin Domain Family 5, Member A, Human Recombinant - 228-22272-1 from RayBiotech Category Protein Species Human

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