GABRA1

Gene Symbol GABRA1
Entrez Gene 2554
Alt Symbol ECA4, EIEE19, EJM, EJM5
Species Human
Gene Type protein-coding
Description gamma-aminobutyric acid (GABA) A receptor, alpha 1
Other Description GABA(A) receptor subunit alpha-1|GABA(A) receptor, alpha 1|gamma-aminobutyric acid receptor subunit alpha-1
Swissprots D3DQK6 P14867 Q8N629
Accessions EAW61537 EAW61538 EAW61539 P14867 AK223447 BAD97167 AK289792 BAF82481 AK295160 BAG58174 AV720972 AW148652 BC030696 AAH30696 BM927274 DA075784 DA228536 DA232066 DB485936 DB487114 DC307259 DC325179 DC334834 DQ890915 ABM81841 R60404 X13584 CAA31925 X14766 CAA32874 NM_000806 NP_000797 NM_001127643 NP_001121115 NM_001127644 NP_001121116 NM_001127645 NP_001121117 NM_001127648 NP_001121120 NM_001127646 NM_001127647
Function Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand- gated chloride channel (By similarity). {ECO:0000250}.
Subcellular Location Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Top Pathways GABAergic synapse, Morphine addiction, Nicotine addiction, Retrograde endocannabinoid signaling, Neuroactive ligand-receptor interaction

GABA A Rα1-6 (E-8) - sc-376282 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
GABA<sub>A</sub> Rα1-6 (E-8): sc-376282. Western blot analysis of GABA<sub>A</sub> Rα1 expression in non-transfected: sc-117752 (A) and human GABA<sub>A</sub> Rα1 transfected: sc-171608 (B) 293T whole cell lysates.

GABA A Rα1 (N-19) - sc-7348 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
GABA<sub>A</sub> Rα1 (N-19): sc-7348. Western blot analysis of GABA<sub>A</sub> Rα1 expression in mouse cerebellum (A) and rat brain (B) tissue extracts.

GABA A Rα1 (T-17) - sc-31403 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
GABA<sub>A</sub> Rα1 (T-17): sc-31403. Western blot analysis of GABA<sub>A</sub> Rα1 expression in Ramos (A), Daoy (B), U-87 MG (C) and Raji (D) whole cell lysates.

GABA A Rα1 (D-18) - sc-31404 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
GABA<sub>A</sub> Rα1 (D-18): sc-31404. Western blot analysis of GABA<sub>A</sub> Rα1 expression in non-transfected: sc-117752 (A) and human GABA<sub>A</sub> Rα1 transfected: sc-171608 (B) 293T whole cell lysates.

GABA A Rα1 (A-20) - sc-31405 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
GABA<sub>A</sub> Rα1 (A-20): sc-31405. Western blot analysis of GABA<sub>A</sub> Rα1 expression in mouse brain (A) and rat brain (B) tissue extracts.

GABA A Rα1-6 (H-300) - sc-14005 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-GABA A Receptor alpha 1 antibody - ab33299 from Abcam

Prices $392.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
ab33299 staining GABA A Receptor alpha 1 in human retinal tissue by Immunohistochemistry (Frozen sections).Tissue was fixed with 4% paraformaldehyde, blocked with 10% donkey serum for 20 minutes at 24°C, then incubated with ab33299 at a 1/100 dilution for 16 hours at 4°C. The secondary antibody used was an Alexa-Fluor 488 (green) conjugated donkey anti-rabbit polyclonal, used at a 1/1000 dilution. Counterstained with Hoechst 33258 (blue).IPL - inner plexiform layerINL - inner nuclear layerOPL - outer plexiform layerONL - outer nuclear layerINS - inner nuclear segmentsSee Abreview

Anti-GABA A Receptor alpha 1 antibody - ab102704 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-GABA A Receptor alpha 1 antibody - ab86320 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-GABA A Receptor alpha 1 antibody (ab86320) at 1 µg/ml + Brain (Human) Membrane Lysate at 10 µgSecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-GABA A Receptor alpha 1 antibody - ab137436 from Abcam

Prices $376.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-GABA A Receptor alpha 1 antibody (ab137436) at 1/1000 dilution + U87-MG whole cell lysate at 30 µg

Anti-GABA A Receptor alpha 1 antibody - ab65269 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-GABA A Receptor alpha 1 antibody (ab65269) at 1/2000 dilution + Ramos (Human Burkitt's lymphoma cell line) Whole Cell Lysate at 10 µgSecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution

Anti-GABA A Receptor alpha 1 antibody - ab32589 from Abcam

Prices $376.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-GABA A Receptor alpha 1 antibody (ab32589) at 1/1000 dilutionLane 1 : Wildtype forebrain lysates 5-7 ugLane 2 : a1 knockout forebrain lysates 5-7 ug

Anti-GABA A Receptor alpha 1 antibody [EPR5401(2)] - ab151573 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5401(2)
All lanes : Anti-GABA A Receptor alpha 1 antibody [EPR5401(2)] (ab151573) at 1/1000 dilutionLane 1 : Human fetal brain lysateLane 2 : Human cerebellum lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilution

Anti-GABA A Receptor alpha 1 antibody [S95-35] - ab94585 from Abcam

Prices $379.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S95-35

Anti-GABRA1 Antibody (aa1-15) - LS-C7001 from LifeSpan Bioscience

Prices $560.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal

Anti-GABRA1 Antibody (N-Terminus) - LS-C7003 from LifeSpan Bioscience

Prices $530.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-GABRA1 Antibody (C-Terminus) - LS-C15283 from LifeSpan Bioscience

Prices $385.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-GABRA1 Antibody - LS-C23737 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-GABRA1 Antibody (Cytoplasmic Domain) - LS-C23741 from LifeSpan Bioscience

Prices $635.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-GABRA1 Antibody - LS-C63372 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-GABRA1 Antibody - LS-C125640 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-GABRA1 Antibody (aa355-394) - LS-C129193 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-GABRA1 Antibody (N-Terminus) - LS-C129192 from LifeSpan Bioscience

Prices $635.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-GABRA1 Antibody (Cytoplasmic Domain) - LS-C193 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western blot of rat forebrain lysates from wild type (Control) and a1-knockout (a1-K/O) animals showing specific immunolabeling of the ~51k a1-subunit of the GABAA-R. The labeling was absent from a lysate prepared from a1-knockout animals.

Anti-GABRA1 Antibody (clone S95-35) - LS-C153133 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S95-35
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