| Gene Symbol | GABRA1 |
|---|---|
| Entrez Gene | 2554 |
| Alt Symbol | ECA4, EIEE19, EJM, EJM5 |
| Species | Human |
| Gene Type | protein-coding |
| Description | gamma-aminobutyric acid (GABA) A receptor, alpha 1 |
| Other Description | GABA(A) receptor subunit alpha-1|GABA(A) receptor, alpha 1|gamma-aminobutyric acid receptor subunit alpha-1 |
| Swissprots | D3DQK6 P14867 Q8N629 |
| Accessions | EAW61537 EAW61538 EAW61539 P14867 AK223447 BAD97167 AK289792 BAF82481 AK295160 BAG58174 AV720972 AW148652 BC030696 AAH30696 BM927274 DA075784 DA228536 DA232066 DB485936 DB487114 DC307259 DC325179 DC334834 DQ890915 ABM81841 R60404 X13584 CAA31925 X14766 CAA32874 NM_000806 NP_000797 NM_001127643 NP_001121115 NM_001127644 NP_001121116 NM_001127645 NP_001121117 NM_001127648 NP_001121120 NM_001127646 NM_001127647 |
| Function | Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand- gated chloride channel (By similarity). {ECO:0000250}. |
| Subcellular Location | Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. |
| Top Pathways | GABAergic synapse, Morphine addiction, Nicotine addiction, Retrograde endocannabinoid signaling, Neuroactive ligand-receptor interaction |