ATN1

Gene Symbol ATN1
Entrez Gene 1822
Alt Symbol B37, D12S755E, DRPLA, HRS, NOD
Species Human
Gene Type protein-coding
Description atrophin 1
Other Description atrophin-1|dentatorubral-pallidoluysian atrophy protein
Swissprots P54259 Q9UEK7 Q99621 Q99495
Accessions AAB51321 BAA23631 EAW88706 EAW88707 EAW88708 P54259 AW411230 BC051795 AAH51795 BE142829 BQ448220 BQ880124 BQ897715 BQ957462 D31840 BAA06626 D38529 BAA07534 EU446506 ABZ92035 U23851 AAB50276 NM_001007026 NP_001007027 NM_001940 NP_001931
Function Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Asn (polyQ) repeats. {ECO:0000250, ECO:0000269|PubMed:10085113, ECO:0000269|PubMed:10973986}.
Subcellular Location Nucleus. Cytoplasm, perinuclear region. Cell junction {ECO:0000250}. Note=Shuttles between nucleus and cytoplasm. Colocalizes with FAT1 in the perinuclear area, at cell- cell junctions and leading edges of cells (By similarity). Colocalizes with MTG8 in discrete nuclear dots. Proteolytic fragment F1 appears to remain in nucleus. Fragment F2 is exported into the cytoplasm. Fragment F2 from mutant sequences with longer poly-Asn (polyQ) tracts are additionally located to the cytoplasmic membrane and to certain organelles. {ECO:0000250}.
Tissue Specificity Widely expressed in various tissues including heart, lung, kidney, ovary, testis, prostate, placenta, skeletal Low levels in the liver, thymus and leukocytes. In the adult brain, broadly expressed in amygdala, caudate nucleus, corpus callosum, hippocampus, hypothalamus, substantia nigra, subthalamic nucleus, and thalamus. High levels in fetal tissues, especially brain. {ECO:0000269|PubMed:7485154, ECO:0000269|PubMed:7842016, ECO:0000269|PubMed:8965642}.

atrophin-1 (A-19) - sc-10302 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
atrophin-1 (A-19): sc-10302. Western blot analysis of atrophin-1 expression in EOC 20 whole cell lysate.

atrophin-1 (C-18) - sc-10304 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

atrophin-1 (N-18) - sc-10301 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
atrophin-1 (N-18): sc-10301. Western blot analysis of atrophin-1 expression in EOC 20 (A) and HeLa (B) whole cell lysates.

atrophin-1 (H-70) - sc-28191 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
atrophin-1 (H-70): sc-28191. Immunofluorescence staining of methanol-fixed EOC 20 cells showing cytoplasmic localization.

Anti-Atrophin 1 antibody - ab32604 from Abcam

Prices $370.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
IHC image of ab32604 staining in Human testis formalin fixed paraffin embedded tissue section, performed on a Leica BondTM system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab32604, 5µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-Atrophin 1 antibody - ab104727 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Atrophin 1 antibody (ab104727) at 1 µg/ml + placenta lysate at 10 µg

Anti-Atrophin 1 antibody - ab55009 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab55009 Atrophin 1 antibody at 1ug/ml.

Anti-Atrophin 1 antibody - ab104728 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Atrophin 1 antibody (ab104728) at 1 µg/ml + 721_B cell lysate at 10 µg

Anti-DRPLA / Atrophin-1 Antibody (aa1100-1150) - LS-C74427 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DRPLA / Atrophin-1 Antibody (C-Terminus) - LS-C74428 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DRPLA / Atrophin-1 Antibody (aa1100-1150) - LS-C287617 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DRPLA / Atrophin-1 Antibody (aa81-130) - LS-C291289 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DRPLA / Atrophin-1 Antibody (C-Terminus) - LS-C287616 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DRPLA / Atrophin-1 Antibody (aa135-180) - LS-C313678 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DRPLA / Atrophin-1 Antibody (aa38-87) - LS-C80083 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Placenta lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 6-18%.

Anti-DRPLA / Atrophin-1 Antibody (N-Terminus) - LS-C80177 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
721_B cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 6-18%.

Anti-DRPLA / Atrophin-1 Antibody (clone 2C10) - LS-C197080 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2C10
Immunofluorescence of monoclonal antibody to ATN1 on HeLa cell . [antibody concentration 10 ug/ml]

ATN1 Antibody - AF6567 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Sheep
Clonality Polyclonal
Western blot shows lysates of human liver tissue and mouse liver tissue. PVDF Membrane was probed with 1 µg/mL of Human/Mouse ATN1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF6567) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # HAF016). Specific bands were detected for ATN1 at approximately 150 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

ATN1 Antibody - NBP1-90044 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: ATN1 Antibody [NBP1-90044] - Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.

ATN1 Antibody (2C10) - H00001822-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2C10
Immunocytochemistry/Immunofluorescence: ATN1 Antibody (2C10) [H00001822-M01] - Analysis of monoclonal antibody to ATN1 on HeLa cell. Antibody concentration 10 ug/ml.

ATN1 Antibody - NB100-2335 from Novus Biologicals

Prices $369.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunoprecipitation: ATN1 Antibody [NB100-2335] - Detection of Human ATN1 on HeLa whole cell lysates using NB100-2335. ATN1 was also immunoprecipitated using rabbit anti-ATN1 antibody NB100-2336.

ATN1 Antibody - NB100-2336 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: ATN1 Antibody [NB100-2336] - Detection of Human Atrophin 1 on HeLa whole cell lysates using NB100-2336. Atrophin 1 was also immunoprecipitated using rabbit anti-Atrophin 1 antibody NB100-2335.

Anti-ATN1 antibody produced in rabbit - HPA031619 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-ATN1: <B>Cat. No. HPA031619</B>: Immunohistochemical staining of human lateral ventricle shows strong nuclear positivity in neuronal cells.

Monoclonal Anti-ATN1 antibody produced in mouse - WH0001822M1 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2C10
<B>Immunoblotting</B><BR/>Monoclonal Anti-ATN1, <B>Cat. No. WH0001822M1</B> used at the antibody concentration: 1 μg/mL. Specific band of ~38.21 kDa using immunogen protein lysate.

Anti-ATN1 (ab2) antibody produced in rabbit - SAB2100176 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-ATN1 (ab2): <B>Cat. No.SAB2100176</B>: ATN1 in Placenta tissue lysate with ATN1 antibody at 1.0 μg/mL.
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