ATN1

Gene Symbol	ATN1
Entrez Gene	1822
Alt Symbol	B37, D12S755E, DRPLA, HRS, NOD
Species	Human
Gene Type	protein-coding
Description	atrophin 1
Other Description	atrophin-1|dentatorubral-pallidoluysian atrophy protein
Swissprots	P54259 Q9UEK7 Q99621 Q99495
Accessions	AAB51321 BAA23631 EAW88706 EAW88707 EAW88708 P54259 AW411230 BC051795 AAH51795 BE142829 BQ448220 BQ880124 BQ897715 BQ957462 D31840 BAA06626 D38529 BAA07534 EU446506 ABZ92035 U23851 AAB50276 NM_001007026 NP_001007027 NM_001940 NP_001931
Function	Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Asn (polyQ) repeats. {ECO:0000250, ECO:0000269|PubMed:10085113, ECO:0000269|PubMed:10973986}.
Subcellular Location	Nucleus. Cytoplasm, perinuclear region. Cell junction {ECO:0000250}. Note=Shuttles between nucleus and cytoplasm. Colocalizes with FAT1 in the perinuclear area, at cell- cell junctions and leading edges of cells (By similarity). Colocalizes with MTG8 in discrete nuclear dots. Proteolytic fragment F1 appears to remain in nucleus. Fragment F2 is exported into the cytoplasm. Fragment F2 from mutant sequences with longer poly-Asn (polyQ) tracts are additionally located to the cytoplasmic membrane and to certain organelles. {ECO:0000250}.
Tissue Specificity	Widely expressed in various tissues including heart, lung, kidney, ovary, testis, prostate, placenta, skeletal Low levels in the liver, thymus and leukocytes. In the adult brain, broadly expressed in amygdala, caudate nucleus, corpus callosum, hippocampus, hypothalamus, substantia nigra, subthalamic nucleus, and thalamus. High levels in fetal tissues, especially brain. {ECO:0000269|PubMed:7485154, ECO:0000269|PubMed:7842016, ECO:0000269|PubMed:8965642}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Atrophin 1 peptide - ab32861 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human Atrophin 1 protein fragment - ab158316 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

DRPLA / Atrophin-1 Antibody Blocking Peptide - LS-E12082 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DRPLA / Atrophin-1 Antibody Blocking Peptide - LS-E13664 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human ATN1 Protein - H00001822-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Atrophin-1 Blocking Peptide - abx062546 from Abbexa Category Peptide Species Human, Mouse, Rat

Atrophin-1 - H00001822-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Atrophin-1 - H00001822-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

ATN1 fusion protein - ag6554 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

ATN1 fusion protein - ag5835 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human ATN1, His-tagged - ATN1-3772H from Creative Biomart Category Protein Source E. Coli or Yeast Species Human

Atrophin-1 Blocking Peptide - CBP1352 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

Atrophin-1 Peptide - BS5625P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Atrophin-1(ATN1) ,partial - CSB-YP002305HU CSB-EP002305HU CSB-BP002305HU CSB-MP002305HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Atrophin-1(ATN1) ,partial, Recombinant Protein - MBS967706 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Recombinant Atrophin 1 (ATN1) - RPC225Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Atrophin 1 (ATN1) - RPC225Hu01 from Cloud-clone Category Protein Source E.coli Species Human

ATN1 Recombinant Protein Antigen - NBP1-90044PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

ATN1 Peptide, Human - M34GP01116H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Atrophin 1 (ATN1) - RPU51314 from Biomatik Category Protein Prices $170.00, $347.00, $531.00, $663.92 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Human

ATN1 Recombinant Protein (OPCD00543) - OPCD00543 from Aviva Systems Biology Category Protein Source E.coli Species Human

ATN1 peptide - orb217215 from Biorbyt Category Peptide Species Human, Mouse, Rat

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