ATN1
| Gene Symbol | ATN1 |
|---|---|
| Entrez Gene | 1822 |
| Alt Symbol | B37, D12S755E, DRPLA, HRS, NOD |
| Species | Human |
| Gene Type | protein-coding |
| Description | atrophin 1 |
| Other Description | atrophin-1|dentatorubral-pallidoluysian atrophy protein |
| Swissprots | P54259 Q9UEK7 Q99621 Q99495 |
| Accessions | AAB51321 BAA23631 EAW88706 EAW88707 EAW88708 P54259 AW411230 BC051795 AAH51795 BE142829 BQ448220 BQ880124 BQ897715 BQ957462 D31840 BAA06626 D38529 BAA07534 EU446506 ABZ92035 U23851 AAB50276 NM_001007026 NP_001007027 NM_001940 NP_001931 |
| Function | Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Asn (polyQ) repeats. {ECO:0000250, ECO:0000269|PubMed:10085113, ECO:0000269|PubMed:10973986}. |
| Subcellular Location | Nucleus. Cytoplasm, perinuclear region. Cell junction {ECO:0000250}. Note=Shuttles between nucleus and cytoplasm. Colocalizes with FAT1 in the perinuclear area, at cell- cell junctions and leading edges of cells (By similarity). Colocalizes with MTG8 in discrete nuclear dots. Proteolytic fragment F1 appears to remain in nucleus. Fragment F2 is exported into the cytoplasm. Fragment F2 from mutant sequences with longer poly-Asn (polyQ) tracts are additionally located to the cytoplasmic membrane and to certain organelles. {ECO:0000250}. |
| Tissue Specificity | Widely expressed in various tissues including heart, lung, kidney, ovary, testis, prostate, placenta, skeletal Low levels in the liver, thymus and leukocytes. In the adult brain, broadly expressed in amygdala, caudate nucleus, corpus callosum, hippocampus, hypothalamus, substantia nigra, subthalamic nucleus, and thalamus. High levels in fetal tissues, especially brain. {ECO:0000269|PubMed:7485154, ECO:0000269|PubMed:7842016, ECO:0000269|PubMed:8965642}. |
atrophin-1 CRISPR/Cas9 KO Plasmid (h) - sc-407398 from Santa Cruz Biotechnology
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atrophin-1 HDR Plasmid (h) - sc-407398-HDR from Santa Cruz Biotechnology
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atrophin-1 Double Nickase Plasmid (h) - sc-407398-NIC from Santa Cruz Biotechnology
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atrophin-1 Double Nickase Plasmid (h2) - sc-407398-NIC-2 from Santa Cruz Biotechnology
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atrophin-1 CRISPR Activation Plasmid (h) - sc-407398-ACT from Santa Cruz Biotechnology
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atrophin-1 CRISPR Activation Plasmid (h2) - sc-407398-ACT-2 from Santa Cruz Biotechnology
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atrophin-1 Lentiviral Activation Particles (h) - sc-407398-LAC from Santa Cruz Biotechnology
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atrophin-1 Lentiviral Activation Particles (h2) - sc-407398-LAC-2 from Santa Cruz Biotechnology
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atrophin-1 siRNA (h) - sc-29765 from Santa Cruz Biotechnology
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atrophin-1 shRNA Plasmid (h) - sc-29765-SH from Santa Cruz Biotechnology
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atrophin-1 shRNA (h) Lentiviral Particles - sc-29765-V from Santa Cruz Biotechnology
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ATN1 RNAi - H00001822-R01 from Novus Biologicals
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ATN1 RNAi - H00001822-R02 from Novus Biologicals
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MISSION® esiRNA - EHU083611 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3664 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3664 from Sigma-Aldrich
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ATN1 siRNA (Human) - CRH1271 from Cohesion Biosciences
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ATN1 - MBS8213641 from MyBioSource
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shRNA set against Human ATN1 (NM_001940.3) - SHH242306 from Creative biogene
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shRNA set against Human ATN1(NM_001007026.1) - SHG080511 from Creative biogene
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Human ATN1 siRNA - orb261773 from Biorbyt
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ATN1 shRNA Plasmid (Human) - CHH1271 from Cohesion Biosciences
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ATN1 miRNA 3'UTR clone - MiUTR1H-00669 from Creative biogene
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ATN1 miRNA 3'UTR clone - MiUTR3H-09242 from Creative biogene
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