HACD2

Gene Symbol HACD2
Entrez Gene 201562
Alt Symbol PTPLB
Species Human
Gene Type protein-coding
Description 3-hydroxyacyl-CoA dehydratase 2
Other Description protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b|protein-tyrosine phosphatase-like member B|very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2|very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 2
Swissprots Q6Y1H2
Accessions Q6Y1H2 AF052159 AK074605 AK289983 BAF82672 AL832532 AY191814 AAP20101 BC016990 BC049369 AAH49369 BC060839 AAH60839 NM_198402 NP_940684
Function Catalyzes the third of the four reactions of the long- chain fatty acids elongation cycle. This endoplasmic reticulum- bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. {ECO:0000269|PubMed:18554506}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:15024066, ECO:0000269|PubMed:18554506}; Multi- pass membrane protein {ECO:0000269|PubMed:15024066, ECO:0000269|PubMed:18554506}.
Tissue Specificity Highly expressed in testis, spleen, prostate, colon and heart, followed by moderate expression in thymus, ovary, small intestine, peripheral blood leukocytes, liver, skeletal muscle and pancreas. Weakly detected in kidney, placenta, brain and lung. {ECO:0000269|PubMed:15024066}.
Top Pathways Fatty acid elongation, Biosynthesis of unsaturated fatty acids, Fatty acid metabolism

PTPLB (C-15) - sc-100104 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PTPLB (C-15): sc-100104. Western blot analysis of PTPLB expression in Hep G2 whole cell lysate.

Anti-PTPLB antibody - ab104106 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-PTPLB antibody (ab104106) at 1/100 dilution + CHO cell lysate at 35 µg

Anti-PTPLB antibody - ab103825 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-PTPLB antibody (ab103825) at 1 µg/ml + Human kidney tissue lysate at 50 µg

Anti-HACD2 / PTPLB Antibody (aa226-254, APC) - LS-C284869 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HACD2 / PTPLB Antibody (aa226-254, Biotin) - LS-C284872 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HACD2 / PTPLB Antibody (aa226-254, AP) - LS-C284867 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HACD2 / PTPLB Antibody (aa226-254, FITC) - LS-C284873 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HACD2 / PTPLB Antibody (aa226-254, Azide-free, HRP) - LS-C284874 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HACD2 / PTPLB Antibody (aa226-254, PE) - LS-C284875 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HACD2 / PTPLB Antibody (aa224-254) - LS-C324415 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HACD2 / PTPLB Antibody (aa226-254) - LS-C162298 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
PTPLB Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human prostate carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.

PTPLB Antibody - H00201562-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: PTPLB Antibody [H00201562-D01P] - Analysis of PTPLB expression in transfected 293T cell line by PTPLB polyclonal antibody.Lane 1: PTPLB transfected lysate(28.40 KDa).Lane 2: Non-transfected lysate.

Anti-PTPLB antibody produced in rabbit - SAB1402046 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Polyclonal Anti-PTPLB, antibody produced in rabbit, purified immunoglobulin: <B>Cat. No. SAB1402046</B>: Antibody concentration: 1.0 - 5.0 μg/mL. Specific band of ~28.37 kDa using human kidney lysate.

PTPLB Antibody - C-terminal region (OAAB02388) - OAAB02388 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

PTPLB-Antibody-C-term - AP4975b from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of lysate from MCF-7 cell line, using PTPLB Antibody (C-term)(Cat. #AP4975b). AP4975b was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug per lane.

PTPLB Antibody - abx032363 from Abbexa

Host Rabbit
Clonality Polyclonal

PTPLB antibody - H00201562-D01P from Acris Antibodies

Prices $390.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
PTPLB MaxPab rabbit polyclonal antibody. Western Blot analysis of PTPLB expression in human kidney.

Rabbit Anti-Human PTPLB (C-term) - 102-15816 from RayBiotech

Host Rabbit

PTPLB antibody (C-term) - STJ49311 from St John's Laboratory Ltd

Host Rabbit
Clonality Polyclonal
Clone RB26055

Anti-PTPLB monoclonal antibody - DCABH-16566 from Creative Diagnostics

Host Rabbit
Clonality Monoclonal

PTPLB Polyclonal Antibody - PA5-24897 from Thermo Fisher Scientific

Prices $349.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis using a PTPLB polyclonal antibody (Product # PA5-24897) in CHO cell lysates (35ug per lane).

PTPLB, Polyclonal Antibody - MBS6011945 from MyBioSource

Prices $550.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

PTPLB, Polyclonal Antibody - MBS9214486 from MyBioSource

Prices $155.00, $340.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal

ANTI-PTPLB (C-TERM) antibody produced in rabbit - SAB1302912 from Sigma-Aldrich

Prices $336.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-PTPLB (C-term): <B>Cat. No. SAB1302912</B>: Western blot analysis of PTPLB Antibody (C-term) in mouse bladder tissue lysates (35 μg/lane).

HACD2 Antibody,Biotin conjugated - CSB-PA761567LD01HU from Cusabio

Host Rabbit
Clonality Polyclonal
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