| Gene Symbol |
HACD2
|
| Entrez Gene |
201562
|
| Alt Symbol |
PTPLB
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
3-hydroxyacyl-CoA dehydratase 2
|
| Other Description |
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b|protein-tyrosine phosphatase-like member B|very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2|very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 2
|
| Swissprots |
Q6Y1H2
|
| Accessions |
Q6Y1H2 AF052159 AK074605 AK289983 BAF82672 AL832532 AY191814 AAP20101 BC016990 BC049369 AAH49369 BC060839 AAH60839 NM_198402 NP_940684
|
| Function |
Catalyzes the third of the four reactions of the long- chain fatty acids elongation cycle. This endoplasmic reticulum- bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. {ECO:0000269|PubMed:18554506}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:15024066, ECO:0000269|PubMed:18554506}; Multi- pass membrane protein {ECO:0000269|PubMed:15024066, ECO:0000269|PubMed:18554506}.
|
| Tissue Specificity |
Highly expressed in testis, spleen, prostate, colon and heart, followed by moderate expression in thymus, ovary, small intestine, peripheral blood leukocytes, liver, skeletal muscle and pancreas. Weakly detected in kidney, placenta, brain and lung. {ECO:0000269|PubMed:15024066}.
|
| Top Pathways |
Fatty acid elongation, Biosynthesis of unsaturated fatty acids, Fatty acid metabolism
|