| Gene Symbol | HACD2 |
|---|---|
| Entrez Gene | 201562 |
| Alt Symbol | PTPLB |
| Species | Human |
| Gene Type | protein-coding |
| Description | 3-hydroxyacyl-CoA dehydratase 2 |
| Other Description | protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b|protein-tyrosine phosphatase-like member B|very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2|very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 2 |
| Swissprots | Q6Y1H2 |
| Accessions | Q6Y1H2 AF052159 AK074605 AK289983 BAF82672 AL832532 AY191814 AAP20101 BC016990 BC049369 AAH49369 BC060839 AAH60839 NM_198402 NP_940684 |
| Function | Catalyzes the third of the four reactions of the long- chain fatty acids elongation cycle. This endoplasmic reticulum- bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. {ECO:0000269|PubMed:18554506}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:15024066, ECO:0000269|PubMed:18554506}; Multi- pass membrane protein {ECO:0000269|PubMed:15024066, ECO:0000269|PubMed:18554506}. |
| Tissue Specificity | Highly expressed in testis, spleen, prostate, colon and heart, followed by moderate expression in thymus, ovary, small intestine, peripheral blood leukocytes, liver, skeletal muscle and pancreas. Weakly detected in kidney, placenta, brain and lung. {ECO:0000269|PubMed:15024066}. |
| Top Pathways | Fatty acid elongation, Biosynthesis of unsaturated fatty acids, Fatty acid metabolism |
PTPLB CRISPR/Cas9 KO Plasmid (h) - sc-415017 from Santa Cruz Biotechnology
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PTPLB HDR Plasmid (h) - sc-415017-HDR from Santa Cruz Biotechnology
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PTPLB Double Nickase Plasmid (h) - sc-415017-NIC from Santa Cruz Biotechnology
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PTPLB Double Nickase Plasmid (h2) - sc-415017-NIC-2 from Santa Cruz Biotechnology
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PTPLB CRISPR Activation Plasmid (h) - sc-415017-ACT from Santa Cruz Biotechnology
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PTPLB CRISPR Activation Plasmid (h2) - sc-415017-ACT-2 from Santa Cruz Biotechnology
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PTPLB Lentiviral Activation Particles (h) - sc-415017-LAC from Santa Cruz Biotechnology
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PTPLB Lentiviral Activation Particles (h2) - sc-415017-LAC-2 from Santa Cruz Biotechnology
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PTPLB siRNA (h) - sc-77916 from Santa Cruz Biotechnology
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PTPLB shRNA Plasmid (h) - sc-77916-SH from Santa Cruz Biotechnology
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PTPLB shRNA (h) Lentiviral Particles - sc-77916-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU142251 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0720 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0719 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0718 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17694 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17694 from Sigma-Aldrich
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PTPLB siRNA (Human) - CRJ6297 from Cohesion Biosciences
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shRNA set against Human PTPLB (NM_198402.3) - SHH386396 from Creative biogene
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shRNA set against Human PTPLB(NM_198402.3) - SHR151692 from Creative biogene
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Human PTPLB siRNA - orb276798 from Biorbyt
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PTPLB shRNA Plasmid (Human) - CHJ6297 from Cohesion Biosciences
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PTPLB miRNA 3'UTR clone - MiUTR1H-08446 from Creative biogene
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